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100 S Main St
Smyrna, DE 19977
Smyrna Health and Wellness Center · Office Property For Sale

Investment Highlights

  • Purpose-built Class A medical office campus in downtown Smyrna.
  • Located within one mile of the Delaware Route 1 interchange.
  • Three-story institutional-quality building on a 3.14-acre site.
  • Approximately 74% leased with established healthcare tenancy.
  • Positioned two blocks from U.S. Route 13 for regional access.
  • Ample parking supports medical and professional office operations.

Executive Summary

100 S Main Street presents an opportunity to acquire a purpose-built Class A medical office asset in the heart of Smyrna, Delaware. Situated on a 3.14-acre campus, the three-story property contains approximately 113,000 square feet and is reported to be 74% leased by regional healthcare tenants. The asset benefits from an established healthcare-oriented tenancy profile and a professionally managed campus environment designed to support long-term medical and office use.
The property's location strengthens its appeal as a regional healthcare destination. Positioned approximately two blocks from Dupont Boulevard (U.S. Route 13) and within one mile of the Delaware Route 1 interchange, the building offers convenient access to both northern and southern Delaware. Smyrna's location between Wilmington and Dover supports access to a broad patient base, workforce population, and surrounding communities. The property is also recognized as part of Smyrna's established medical district, creating proximity to complementary healthcare services and providers.
The combination of existing occupancy, institutional-quality construction, regional accessibility, and healthcare-focused positioning provides investors with an asset that serves a critical community function while benefiting from Delaware's central transportation network. Its campus setting, parking availability, and visibility along a well-established commercial corridor further contribute to its long-term relevance for healthcare and professional office users.

Property Facts

Sale Type
Investment
Property Type
Office
Property Subtype
Medical
Building Size
113,094 SF
Building Class
A
Year Built
2006
Percent Leased
87%
Tenancy
Multiple
Building Height
3 Stories
Typical Floor Size
37,698 SF
Slab To Slab
10’
Building FAR
0.75
Lot Size
3.44 AC
Zoning
M - Manufacturing
Parking
156 Spaces (1.38 Spaces per 1,000 SF Leased)

Amenities

  • Signage

Property Taxes

Property Taxes

Parcel Number
1-17-01018-01-0300-000
Land Assessment
$259,600
Improvements Assessment
$16,396,100
Total Assessment
$16,655,700
  • Listing ID: 41753856

  • Date on Market: 8/14/2026

  • Last Updated:

  • Address: 100 S Main St, Smyrna, DE 19977

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