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Building 5 181 Oyster Point Blvd 33,771 - 143,644 SF of 4-Star Space Available in South San Francisco, CA 94080

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SUBLEASE HIGHLIGHTS

  • Unique opportunity within Class-A life science campus.
  • Divisible by Floor.
  • Fully furnished office spaces | Campus environment with shared outdoor spaces.

FEATURES

Standard Parking Spaces
410

ALL AVAILABLE SPACES(4)

Display Rental Rate as

  • SPACE
  • SIZE
  • TERM
  • RENTAL RATE
  • SPACE USE
  • CONDITION
  • AVAILABLE
  • 2nd Floor
  • 33,771 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now

Life Science Sublease Opportunity.

  • Sublease space available from current tenant
  • Mostly Open Floor Plan Layout
  • Fully Built-Out as Research and Development Space
  • Space is in Excellent Condition
  • 3rd Floor
  • 36,884 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now

Office Space.

  • Sublease space available from current tenant
  • Mostly Open Floor Plan Layout
  • Fully Built-Out as Standard Office
  • Space is in Excellent Condition
  • 4th Floor
  • 36,838 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Shell Space
  • Now

Life Science Sublease Opportunity.

  • Sublease space available from current tenant
  • Space is in Excellent Condition
  • Open Floor Plan Layout
  • Can be combined with additional space(s) for up to 72,989 SF of adjacent space
  • 5th Floor
  • 36,151 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Flex
  • Full Build-Out
  • Now

Life Science Sublease. Unique Opportunity Within Garage parking with EV charging Campus environment with shared outdoor spaces Class-A Life Science Campus.

  • Sublease space available from current tenant
  • Can be combined with additional space(s) for up to 72,989 SF of adjacent space
  • Security Personnel
  • First Class Hotel
  • Large & Small Sitting Areas
  • Space is in Excellent Condition
  • Private Conference Room
  • Free WiFi
  • Lobby Ambassador
Space Size Term Rental Rate Space Use Condition Available
2nd Floor 33,771 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now
3rd Floor 36,884 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now
4th Floor 36,838 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Shell Space Now
5th Floor 36,151 SF Negotiable Upon Request Upon Request Upon Request Upon Request Flex Full Build-Out Now

2nd Floor

Size
33,771 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
Full Build-Out
Available
Now

3rd Floor

Size
36,884 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
Full Build-Out
Available
Now

4th Floor

Size
36,838 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
Shell Space
Available
Now

5th Floor

Size
36,151 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Flex
Condition
Full Build-Out
Available
Now

2nd Floor

Size 33,771 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition Full Build-Out
Available Now

Life Science Sublease Opportunity.

  • Sublease space available from current tenant
  • Fully Built-Out as Research and Development Space
  • Mostly Open Floor Plan Layout
  • Space is in Excellent Condition

3rd Floor

Size 36,884 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition Full Build-Out
Available Now

Office Space.

  • Sublease space available from current tenant
  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Space is in Excellent Condition

4th Floor

Size 36,838 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition Shell Space
Available Now

Life Science Sublease Opportunity.

  • Sublease space available from current tenant
  • Open Floor Plan Layout
  • Space is in Excellent Condition
  • Can be combined with additional space(s) for up to 72,989 SF of adjacent space

5th Floor

Size 36,151 SF
Term Negotiable
Rental Rate Upon Request
Space Use Flex
Condition Full Build-Out
Available Now

Life Science Sublease. Unique Opportunity Within Garage parking with EV charging Campus environment with shared outdoor spaces Class-A Life Science Campus.

  • Sublease space available from current tenant
  • Space is in Excellent Condition
  • Can be combined with additional space(s) for up to 72,989 SF of adjacent space
  • Private Conference Room
  • Security Personnel
  • Free WiFi
  • First Class Hotel
  • Lobby Ambassador
  • Large & Small Sitting Areas

PROPERTY OVERVIEW

Discover the advantages of establishing your business at The Cove at Oyster Point, a feature-packed Class-A campus situated at the epicenter of the South San Francisco life science cluster. 181 Oyster Point presents 164,150 square feet of cutting-edge lab and office space. Abundant on-site and nearby amenities enhance the work environment, while seamless accessibility is ensured through convenient connections to US-101 and shuttle services to BART, Caltrain, and Ferry service.

PROPERTY FACTS

Building Size
164,150 SF
Lot Size
1.80 AC
Year Built
2020
Construction
Steel

ATTACHMENTS

Brochure
  • Listing ID: 31293102

  • Date on Market: 8/29/2025

  • Last Updated:

  • Address: 181 Oyster Point Blvd, South San Francisco, CA 94080

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