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TMC Innovation Factory 2450 Holcombe Rd 1,560 - 85,021 SF of Space Available in Houston, TX 77021

Office Spaces Texas Houston 2450 Holcombe Rd, Houston, TX 77021

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ALL AVAILABLE SPACES(10)

Display Rental Rate as

  • SPACE
  • SIZE
  • TERM
  • RENTAL RATE
  • SPACE USE
  • CONDITION
  • AVAILABLE
  • 1st Floor, Ste 1330
  • 3,267 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Floor Plan
  • Fully Built-Out as Standard Office
  • Space is in Excellent Condition
  • Mostly Open Floor Plan Layout
  • 1st Floor, Ste 1340 A
  • 4,070 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • 30 Days
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 1 of 1
Floor Plan
  • 1st Floor, Ste 1340 B
  • 1,560 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • 30 Days
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 1 of 1
Floor Plan
  • 1st Floor - 1410
  • 6,146 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Flex
  • Full Build-Out
  • Now
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 1
Interior Photo
  • Space is in Excellent Condition
  • 1st Floor, Ste Suite 1600
  • 28,070 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Spec Suite
  • Now
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Floor Plan

Wet-lab spec suite designed at a 60/40 lab/office ratio. FF&E included.

  • Open Floor Plan Layout
  • Laboratory
  • Space is in Excellent Condition
  • 1st Floor, Ste Suite E
  • 9,796 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now
  • Fully Built-Out as Standard Medical Space
  • Space is in Excellent Condition
  • Office intensive layout
  • 2nd Floor, Ste 2000
  • 10,000 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 5
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 2 of 5
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 3 of 5
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 4 of 5
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Site Plan- Image 5 of 5
Site Plan

2nd generation office

  • Fully Built-Out as Standard Office
  • Space is in Excellent Condition
  • Office intensive layout
  • 2nd Floor, Ste Suite 2220
  • 4,920 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Shell Space
  • Now
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Floor Plan
  • Open Floor Plan Layout
  • Space is in Excellent Condition
  • 2nd Floor, Ste Suite 2240
  • 4,187 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Shell Space
  • Now
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Floor Plan

Office Shell

  • Open Floor Plan Layout
  • 2nd Floor, Ste Suite 2250
  • 13,005 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Floor Plan

Former Dry Lab

  • Fully Built-Out as Standard Office
  • Space is in Excellent Condition
  • Office intensive layout
Space Size Term Rental Rate Space Use Condition Available
1st Floor, Ste 1330 3,267 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now
1st Floor, Ste 1340 A 4,070 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - 30 Days
1st Floor, Ste 1340 B 1,560 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - 30 Days
1st Floor - 1410 6,146 SF Negotiable Upon Request Upon Request Upon Request Upon Request Flex Full Build-Out Now
1st Floor, Ste Suite 1600 28,070 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Spec Suite Now
1st Floor, Ste Suite E 9,796 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
2nd Floor, Ste 2000 10,000 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now
2nd Floor, Ste Suite 2220 4,920 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Shell Space Now
2nd Floor, Ste Suite 2240 4,187 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Shell Space Now
2nd Floor, Ste Suite 2250 13,005 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now

1st Floor, Ste 1330

Size
3,267 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
Full Build-Out
Available
Now

1st Floor, Ste 1340 A

Size
4,070 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
30 Days

1st Floor, Ste 1340 B

Size
1,560 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
30 Days

1st Floor - 1410

Size
6,146 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Flex
Condition
Full Build-Out
Available
Now

1st Floor, Ste Suite 1600

Size
28,070 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Spec Suite
Available
Now

1st Floor, Ste Suite E

Size
9,796 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

2nd Floor, Ste 2000

Size
10,000 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
Full Build-Out
Available
Now

2nd Floor, Ste Suite 2220

Size
4,920 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
Shell Space
Available
Now

2nd Floor, Ste Suite 2240

Size
4,187 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
Shell Space
Available
Now

2nd Floor, Ste Suite 2250

Size
13,005 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
Full Build-Out
Available
Now
1 of 2
VIDEOS
MATTERPORT 3D EXTERIOR
MATTERPORT 3D TOUR
PHOTOS
STREET VIEW STREET
MAP
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Suite 1330 Floor Plan
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Suite 1330 Floor Plan

1st Floor, Ste 1330

2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Floor Plan
Size 3,267 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition Full Build-Out
Available Now

  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Space is in Excellent Condition
1 of 1
VIDEOS
MATTERPORT 3D EXTERIOR
MATTERPORT 3D TOUR
PHOTOS
STREET VIEW STREET
MAP
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 1 of 1
Suite 1340 A Floor Plan

1st Floor, Ste 1340 A

2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 1 of 1
Floor Plan
Size 4,070 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition -
Available 30 Days

1 of 1
VIDEOS
MATTERPORT 3D EXTERIOR
MATTERPORT 3D TOUR
PHOTOS
STREET VIEW STREET
MAP
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 1 of 1
Suite 1340 B Floor Plan

1st Floor, Ste 1340 B

2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 1 of 1
Floor Plan
Size 1,560 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition -
Available 30 Days

1 of 1
VIDEOS
MATTERPORT 3D EXTERIOR
MATTERPORT 3D TOUR
PHOTOS
STREET VIEW STREET
MAP
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 1
Suite 1410 Floor Plan

1st Floor - 1410

2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 1
Interior Photo
Size 6,146 SF
Term Negotiable
Rental Rate Upon Request
Space Use Flex
Condition Full Build-Out
Available Now

  • Space is in Excellent Condition
1 of 2
VIDEOS
MATTERPORT 3D EXTERIOR
MATTERPORT 3D TOUR
PHOTOS
STREET VIEW STREET
MAP
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Suite 1600 Floor Plan 28K JPG
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Suite 1600 Floor Plan

1st Floor, Ste Suite 1600

2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Floor Plan
Size 28,070 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Spec Suite
Available Now

Wet-lab spec suite designed at a 60/40 lab/office ratio. FF&E included.

  • Open Floor Plan Layout
  • Space is in Excellent Condition
  • Laboratory

1st Floor, Ste Suite E

Size 9,796 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

  • Fully Built-Out as Standard Medical Space
  • Office intensive layout
  • Space is in Excellent Condition
1 of 5
VIDEOS
MATTERPORT 3D EXTERIOR
MATTERPORT 3D TOUR
PHOTOS
STREET VIEW STREET
MAP
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 5
Suite Entrance
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 2 of 5
Conference Room
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 3 of 5
Office
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 4 of 5
Break Area
2450 Holcombe Rd, Houston, TX for lease Site Plan- Image 5 of 5
Suite 2000 Floor Plan

2nd Floor, Ste 2000

2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 5
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 2 of 5
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 3 of 5
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 4 of 5
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Site Plan- Image 5 of 5
Site Plan
Size 10,000 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition Full Build-Out
Available Now

2nd generation office

  • Fully Built-Out as Standard Office
  • Office intensive layout
  • Space is in Excellent Condition
1 of 2
VIDEOS
MATTERPORT 3D EXTERIOR
MATTERPORT 3D TOUR
PHOTOS
STREET VIEW STREET
MAP
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Suite 2220 Floor Plan New
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Suite 2220 Floor Plan

2nd Floor, Ste Suite 2220

2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Floor Plan
Size 4,920 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition Shell Space
Available Now

  • Open Floor Plan Layout
  • Space is in Excellent Condition
1 of 2
VIDEOS
MATTERPORT 3D EXTERIOR
MATTERPORT 3D TOUR
PHOTOS
STREET VIEW STREET
MAP
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Suite 2240 Floor Plan New
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Suite 2240 Floor Plan

2nd Floor, Ste Suite 2240

2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Floor Plan
Size 4,187 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition Shell Space
Available Now

Office Shell

  • Open Floor Plan Layout
1 of 2
VIDEOS
MATTERPORT 3D EXTERIOR
MATTERPORT 3D TOUR
PHOTOS
STREET VIEW STREET
MAP
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Suite 2250 Floor Plan
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Suite 2250 Floor Plan

2nd Floor, Ste Suite 2250

2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 1 of 2
Interior Photo
2450 Holcombe Rd, Houston, TX for lease Floor Plan- Image 2 of 2
Floor Plan
Size 13,005 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition Full Build-Out
Available Now

Former Dry Lab

  • Fully Built-Out as Standard Office
  • Office intensive layout
  • Space is in Excellent Condition

PROPERTY OVERVIEW

What was once a Nabisco cookie factory now drives TMC’s diverse alliance of early-stage innovators. The TMC Innovation Factory empowers entrepreneurs from across the world to push the limits of discovery and bring their solutions to life faster with the support of industry partners, TMCi programming, and the greater TMC ecosystem.

  • Bio-Tech/ Lab Space
  • Conferencing Facility
  • Convenience Store
  • Property Manager on Site
  • Security System
  • Storage Space

PROPERTY FACTS

Building Type
Office
Year Built/Renovated
1948/2021
Building Height
2 Stories
Building Size
650,000 SF
Building Class
A
Typical Floor Size
325,000 SF
Unfinished Ceiling Height
12’
Parking
Surface Parking
Covered Parking
Reserved Parking

ATTACHMENTS

Fact Sheet Brochure_TMC Innovation
TMC Innovation Factory Leasing 2025
TMC Innovation Factory Leasing Presentation

LINKS

1 1
(713) 270-0457

Still interested?

Contact the brokers for more information about this property

CONTACTS

  • Listing ID: 22852610

  • Date on Market: 9/26/2025

  • Last Updated:

  • Address: 2450 Holcombe Rd, Houston, TX 77021

More public record information on 2450 Holcombe Rd, Houston, TX 77021

The Medical Center South Office Property at 2450 Holcombe Rd, Houston, TX 77021 is currently available. Contact Transwestern Real Estate Services for more information.

OFFICE PROPERTIES IN NEARBY NEIGHBORHOODS

NEARBY LISTINGS

1 of 18
VIDEOS
MATTERPORT 3D EXTERIOR
MATTERPORT 3D TOUR
PHOTOS
STREET VIEW STREET
MAP
2450 Holcombe Rd, Houston, TX for lease Building Photo- Image 1 of 18
SQFT-8065
2450 Holcombe Rd, Houston, TX for lease Building Photo- Image 2 of 18
SQFT - 8040
2450 Holcombe Rd, Houston, TX for lease Building Photo- Image 3 of 18
SQFT - 8125
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 4 of 18
21_1028_Nabisco_Lab Render
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 5 of 18
Lab Office Opt 1
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 6 of 18
Reception
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 7 of 18
21_1028_Nabisco_Office Render
2450 Holcombe Rd, Houston, TX for lease Building Photo- Image 8 of 18
SWFT-8150
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 9 of 18
SQFT - 0104
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 10 of 18
SQFT-0319
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 11 of 18
SQFT-0244
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 12 of 18
SQFT-0685
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 13 of 18
SQFT-0369
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 14 of 18
SQFT-0114
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 15 of 18
SQFT-0184
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 16 of 18
SQFT-0514
2450 Holcombe Rd, Houston, TX for lease Interior Photo- Image 17 of 18
SQFT-0139
1 of 1

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TMC Innovation Factory | 2450 Holcombe Rd

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