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Los Portales Center 2480 Mission St 445 - 17,068 SF of Office/Medical Space Available in San Francisco, CA 94110
Highlights
- Surrounded by top neighborhood amenities including popular restaurants, cafés, and cultural destinations.
- On-site secure parking garage offering added convenience for tenants and clients.
- Prime Mission District location with immediate access to BART and MUNI for seamless regional connectivity.
- Diverse mix of medical and professional tenants creating a synergistic environment for healthcare and service providers.
All Available Spaces(13)
Display Rental Rate as
- Space
- Size
- Term
- Rental Rate
- Space Use
- Condition
- Available
Street level office, with access to the street and to the lobby inside the building. Conveniently accessible and could fit all sorts of businesses, including startups, professional, medical,spa, physical therapy, financial, etc.
- Lease rate does not include utilities, property expenses or building services
- 1 Conference Room
- 5 Private Offices
- Highly sought after space in the Mission District.
Professional office suite suited for small practices or administrative use.
- Fully Built-Out as Standard Office
- Finished Ceilings: 8’
- Office intensive layout
- Space In Need of Renovation
Plumbed dental layout featuring two operatory rooms designed for clinical workflow.
- Fully Built-Out as Standard Office
- Finished Ceilings: 8’
- Mostly Open Floor Plan Layout
- Space In Need of Renovation
Efficient office suite suitable for solo practitioners or small teams.
- Fully Built-Out as Standard Office
- Finished Ceilings: 8’
- Mostly Open Floor Plan Layout
- Space In Need of Renovation
Compact professional office ideal for therapy, counseling, or private practice use.
- Fully Built-Out as Standard Office
- Finished Ceilings: 8’
- Mostly Open Floor Plan Layout
Large upper-floor office offering flexibility for team-based workspace needs.
- Lease rate does not include utilities, property expenses or building services
- Mostly Open Floor Plan Layout
- High End Trophy Space
- Fully Built-Out as Standard Office
- Finished Ceilings: 8’
- Beautifully remodeled.
1,109 square foot office/medical space along with a mix of private offices available. Second-floor dental layout with two plumbed operatories.
- Fully Built-Out as Standard Medical Space
- 2 Private Offices
- Private Restrooms
- Tenant improvement help available.
- Mostly Open Floor Plan Layout
- Finished Ceilings: 8’
- Wheelchair Accessible
1,129 square foot office/medical space along with a mix of private offices available. Versatile office suite with efficient workspace configuration.
- Fully Built-Out as Standard Medical Space
- 2 Private Offices
- Space is in Excellent Condition
- Mostly Open Floor Plan Layout
- Finished Ceilings: 8’
- Private Restrooms
1,009 square foot office/medical space along with a mix of private offices available. Private office space positioned for professional services or wellness practices.
- Fully Built-Out as Dental Office Space
- 3 Private Offices
- Space is in Excellent Condition
- Wheelchair Accessible
- Mostly Open Floor Plan Layout
- Finished Ceilings: 8’
- Private Restrooms
2,548 square foot office/medical space along with a mix of private offices available. Combined second-floor dental suite featuring four fully plumbed operatories.
- Fully Built-Out as Dental Office Space
- 4 Private Offices
- Space is in Excellent Condition
- Wheelchair Accessible
- Mostly Open Floor Plan Layout
- Finished Ceilings: 8’
- Private Restrooms
1,176 square foot office/medical space along with a mix of private offices available. Bright and functional office suitable for a growing professional practice.
- Fully Built-Out as Dental Office Space
- 3 Private Offices
- Space is in Excellent Condition
- Mostly Open Floor Plan Layout
- Finished Ceilings: 8’
- Private Restrooms
918 square foot office/medical space along with a mix of private offices available. Well-configured professional suite for clinical or general office users.
- Fully Built-Out as Dental Office Space
- 2 Private Offices
- Space is in Excellent Condition
- Wheelchair Accessible
- Mostly Open Floor Plan Layout
- Finished Ceilings: 8’
- Private Restrooms
Efficient office layout for private practitioners or small teams.
- Fully Built-Out as Standard Office
- Finished Ceilings: 8’
- Mostly Open Floor Plan Layout
| Space | Size | Term | Rental Rate | Space Use | Condition | Available |
| 1st Floor, Ste 103 | 2,260 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Partial Build-Out | May 01, 2026 |
| 1st Floor, Ste 104 | 975 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Full Build-Out | Now |
| 1st Floor, Ste 106 | 992 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Full Build-Out | Now |
| 1st Floor, Ste 107 A | 727 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Full Build-Out | Now |
| 1st Floor, Ste 107 B | 445 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Full Build-Out | Now |
| 2nd Floor, Ste 212 | 2,854 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Full Build-Out | Now |
| 2nd Floor, Ste 214 | 1,109 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Full Build-Out | Now |
| 2nd Floor, Ste 216 | 1,129 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Full Build-Out | Now |
| 2nd Floor, Ste 217 | 1,009 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Full Build-Out | Now |
| 2nd Floor, Ste 218-219 | 2,548 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Full Build-Out | Now |
| 2nd Floor, Ste 220 | 1,176 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Full Build-Out | Now |
| 2nd Floor, Ste 221 | 918 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Full Build-Out | Now |
| 2nd Floor, Ste 222 | 926 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office/Medical | Full Build-Out | Now |
1st Floor, Ste 103
| Size |
| 2,260 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Partial Build-Out |
| Available |
| May 01, 2026 |
1st Floor, Ste 104
| Size |
| 975 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Full Build-Out |
| Available |
| Now |
1st Floor, Ste 106
| Size |
| 992 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Full Build-Out |
| Available |
| Now |
1st Floor, Ste 107 A
| Size |
| 727 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Full Build-Out |
| Available |
| Now |
1st Floor, Ste 107 B
| Size |
| 445 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Full Build-Out |
| Available |
| Now |
2nd Floor, Ste 212
| Size |
| 2,854 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Full Build-Out |
| Available |
| Now |
2nd Floor, Ste 214
| Size |
| 1,109 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Full Build-Out |
| Available |
| Now |
2nd Floor, Ste 216
| Size |
| 1,129 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Full Build-Out |
| Available |
| Now |
2nd Floor, Ste 217
| Size |
| 1,009 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Full Build-Out |
| Available |
| Now |
2nd Floor, Ste 218-219
| Size |
| 2,548 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Full Build-Out |
| Available |
| Now |
2nd Floor, Ste 220
| Size |
| 1,176 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Full Build-Out |
| Available |
| Now |
2nd Floor, Ste 221
| Size |
| 918 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Full Build-Out |
| Available |
| Now |
2nd Floor, Ste 222
| Size |
| 926 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office/Medical |
| Condition |
| Full Build-Out |
| Available |
| Now |
1st Floor, Ste 103
| Size | 2,260 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Partial Build-Out |
| Available | May 01, 2026 |
Street level office, with access to the street and to the lobby inside the building. Conveniently accessible and could fit all sorts of businesses, including startups, professional, medical,spa, physical therapy, financial, etc.
- Lease rate does not include utilities, property expenses or building services
- 5 Private Offices
- 1 Conference Room
- Highly sought after space in the Mission District.
1st Floor, Ste 104
| Size | 975 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Full Build-Out |
| Available | Now |
Professional office suite suited for small practices or administrative use.
- Fully Built-Out as Standard Office
- Office intensive layout
- Finished Ceilings: 8’
- Space In Need of Renovation
1st Floor, Ste 106
| Size | 992 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Full Build-Out |
| Available | Now |
Plumbed dental layout featuring two operatory rooms designed for clinical workflow.
- Fully Built-Out as Standard Office
- Mostly Open Floor Plan Layout
- Finished Ceilings: 8’
- Space In Need of Renovation
1st Floor, Ste 107 A
| Size | 727 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Full Build-Out |
| Available | Now |
Efficient office suite suitable for solo practitioners or small teams.
- Fully Built-Out as Standard Office
- Mostly Open Floor Plan Layout
- Finished Ceilings: 8’
- Space In Need of Renovation
1st Floor, Ste 107 B
| Size | 445 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Full Build-Out |
| Available | Now |
Compact professional office ideal for therapy, counseling, or private practice use.
- Fully Built-Out as Standard Office
- Mostly Open Floor Plan Layout
- Finished Ceilings: 8’
2nd Floor, Ste 212
| Size | 2,854 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Full Build-Out |
| Available | Now |
Large upper-floor office offering flexibility for team-based workspace needs.
- Lease rate does not include utilities, property expenses or building services
- Fully Built-Out as Standard Office
- Mostly Open Floor Plan Layout
- Finished Ceilings: 8’
- High End Trophy Space
- Beautifully remodeled.
2nd Floor, Ste 214
| Size | 1,109 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Full Build-Out |
| Available | Now |
1,109 square foot office/medical space along with a mix of private offices available. Second-floor dental layout with two plumbed operatories.
- Fully Built-Out as Standard Medical Space
- Mostly Open Floor Plan Layout
- 2 Private Offices
- Finished Ceilings: 8’
- Private Restrooms
- Wheelchair Accessible
- Tenant improvement help available.
2nd Floor, Ste 216
| Size | 1,129 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Full Build-Out |
| Available | Now |
1,129 square foot office/medical space along with a mix of private offices available. Versatile office suite with efficient workspace configuration.
- Fully Built-Out as Standard Medical Space
- Mostly Open Floor Plan Layout
- 2 Private Offices
- Finished Ceilings: 8’
- Space is in Excellent Condition
- Private Restrooms
2nd Floor, Ste 217
| Size | 1,009 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Full Build-Out |
| Available | Now |
1,009 square foot office/medical space along with a mix of private offices available. Private office space positioned for professional services or wellness practices.
- Fully Built-Out as Dental Office Space
- Mostly Open Floor Plan Layout
- 3 Private Offices
- Finished Ceilings: 8’
- Space is in Excellent Condition
- Private Restrooms
- Wheelchair Accessible
2nd Floor, Ste 218-219
| Size | 2,548 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Full Build-Out |
| Available | Now |
2,548 square foot office/medical space along with a mix of private offices available. Combined second-floor dental suite featuring four fully plumbed operatories.
- Fully Built-Out as Dental Office Space
- Mostly Open Floor Plan Layout
- 4 Private Offices
- Finished Ceilings: 8’
- Space is in Excellent Condition
- Private Restrooms
- Wheelchair Accessible
2nd Floor, Ste 220
| Size | 1,176 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Full Build-Out |
| Available | Now |
1,176 square foot office/medical space along with a mix of private offices available. Bright and functional office suitable for a growing professional practice.
- Fully Built-Out as Dental Office Space
- Mostly Open Floor Plan Layout
- 3 Private Offices
- Finished Ceilings: 8’
- Space is in Excellent Condition
- Private Restrooms
2nd Floor, Ste 221
| Size | 918 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Full Build-Out |
| Available | Now |
918 square foot office/medical space along with a mix of private offices available. Well-configured professional suite for clinical or general office users.
- Fully Built-Out as Dental Office Space
- Mostly Open Floor Plan Layout
- 2 Private Offices
- Finished Ceilings: 8’
- Space is in Excellent Condition
- Private Restrooms
- Wheelchair Accessible
2nd Floor, Ste 222
| Size | 926 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office/Medical |
| Condition | Full Build-Out |
| Available | Now |
Efficient office layout for private practitioners or small teams.
- Fully Built-Out as Standard Office
- Mostly Open Floor Plan Layout
- Finished Ceilings: 8’
Property Overview
Located in San Francisco’s vibrant Mission District, 2480 Mission Street serves as a premier destination for medical, dental, wellness, and professional office users seeking a central, well-managed environment. The building offers a wide spectrum of suites, many of which are already configured for healthcare providers with plumbed operatories ready for immediate use. With flexible suite sizes and the option to combine spaces, tenants can scale operations as their practice grows. The property is positioned steps from BART and MUNI, providing seamless transit access across the Bay Area, and is surrounded by some of the Mission’s most beloved restaurants, cafés, and cultural institutions, creating an energetic and walkable atmosphere for both clients and staff. On-site parking with secure garage access via San Carlos Street further enhances convenience, while an attentive building management team ensures day-to-day operational support. The building maintains a professional environment tailored to medical providers, therapy practices, startups, and service-oriented businesses, offering a modern lobby, flexible configurations, and a community of complementary tenants. With its central location, excellent transit connectivity, and strong roster of professional and medical occupants, 2480 Mission Street stands as an exceptional opportunity for tenants seeking a well-positioned and highly serviceable office setting in one of the city’s most dynamic neighborhoods.
- 24 Hour Access
- Wheelchair Accessible
- Roof Terrace
Property Facts
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Los Portales Center | 2480 Mission St
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