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Los Portales Center 2480 Mission St 445 - 16,430 SF of Office/Medical Space Available in San Francisco, CA 94110

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HIGHLIGHTS

  • Premier office Building in the heart of the Mission District
  • Tenants' onsite parking garage
  • Excellent public transportation - Muni and BART (24th & Mission)
  • Elevator served

ALL AVAILABLE SPACES(14)

Display Rental Rate as

  • SPACE
  • SIZE
  • TERM
  • RENTAL RATE
  • SPACE USE
  • CONDITION
  • AVAILABLE
  • 1st Floor, Ste 104
  • 975 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

Office Space

  • Fully Built-Out as Standard Office
  • Finished Ceilings: 8’
  • Office intensive layout
  • Space In Need of Renovation
  • 1st Floor, Ste 106
  • 992 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

office/ Dental/Medical

  • Fully Built-Out as Standard Office
  • Finished Ceilings: 8’
  • Mostly Open Floor Plan Layout
  • Space In Need of Renovation
  • 1st Floor, Ste 107 A
  • 727 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

Office

  • Fully Built-Out as Standard Office
  • Finished Ceilings: 8’
  • Mostly Open Floor Plan Layout
  • Space In Need of Renovation
  • 1st Floor, Ste 107 B
  • 445 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

Office

  • Fully Built-Out as Standard Office
  • Finished Ceilings: 8’
  • Mostly Open Floor Plan Layout
  • 1st Floor, Ste 109
  • 1,054 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now
  • Fully Built-Out as Standard Office
  • Finished Ceilings: 8’
  • Mostly Open Floor Plan Layout
  • Space In Need of Renovation
  • 1st Floor, Ste 110
  • 568 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

office

  • Fully Built-Out as Standard Office
  • Finished Ceilings: 8’
  • Mostly Open Floor Plan Layout
  • 2nd Floor, Ste 212
  • 2,854 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

Beautifully remodeled, ready.

  • Lease rate does not include utilities, property expenses or building services
  • Mostly Open Floor Plan Layout
  • High End Trophy Space
  • Fully Built-Out as Standard Office
  • Finished Ceilings: 8’
  • 2nd Floor, Ste 214
  • 1,109 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

1,109 square foot office/medical space along with a mix of private offices available. Complete 2 dental opt plumbing in place. Tenant improvement help available.

  • Fully Built-Out as Standard Medical Space
  • 2 Private Offices
  • Private Restrooms
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’
  • Wheelchair Accessible
  • 2nd Floor, Ste 216
  • 1,129 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

1,129 square foot office/medical space along with a mix of private offices available.

  • Fully Built-Out as Standard Medical Space
  • 2 Private Offices
  • Space is in Excellent Condition
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’
  • Private Restrooms
  • 2nd Floor, Ste 217
  • 1,009 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

1,009 square foot office/medical space along with a mix of private offices available.

  • Fully Built-Out as Dental Office Space
  • 3 Private Offices
  • Space is in Excellent Condition
  • Wheelchair Accessible
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’
  • Private Restrooms
  • 2nd Floor, Ste 218-219
  • 2,548 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

2,548 square foot office/medical space along with a mix of private offices available. Complete 4 dental opts plumbing in place.

  • Fully Built-Out as Dental Office Space
  • 4 Private Offices
  • Space is in Excellent Condition
  • Wheelchair Accessible
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’
  • Private Restrooms
  • 2nd Floor, Ste 220
  • 1,176 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

1,176 square foot office/medical space along with a mix of private offices available.

  • Fully Built-Out as Dental Office Space
  • 3 Private Offices
  • Space is in Excellent Condition
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’
  • Private Restrooms
  • 2nd Floor, Ste 221
  • 918 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

918 square foot office/medical space along with a mix of private offices available.

  • Fully Built-Out as Dental Office Space
  • 2 Private Offices
  • Space is in Excellent Condition
  • Wheelchair Accessible
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’
  • Private Restrooms
  • 2nd Floor, Ste 222
  • 926 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now
  • Fully Built-Out as Standard Office
  • Finished Ceilings: 8’
  • Mostly Open Floor Plan Layout
Space Size Term Rental Rate Space Use Condition Available
1st Floor, Ste 104 975 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
1st Floor, Ste 106 992 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
1st Floor, Ste 107 A 727 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
1st Floor, Ste 107 B 445 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
1st Floor, Ste 109 1,054 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
1st Floor, Ste 110 568 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
2nd Floor, Ste 212 2,854 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
2nd Floor, Ste 214 1,109 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
2nd Floor, Ste 216 1,129 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
2nd Floor, Ste 217 1,009 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
2nd Floor, Ste 218-219 2,548 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
2nd Floor, Ste 220 1,176 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
2nd Floor, Ste 221 918 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
2nd Floor, Ste 222 926 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now

1st Floor, Ste 104

Size
975 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

1st Floor, Ste 106

Size
992 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

1st Floor, Ste 107 A

Size
727 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

1st Floor, Ste 107 B

Size
445 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

1st Floor, Ste 109

Size
1,054 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

1st Floor, Ste 110

Size
568 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

2nd Floor, Ste 212

Size
2,854 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

2nd Floor, Ste 214

Size
1,109 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

2nd Floor, Ste 216

Size
1,129 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

2nd Floor, Ste 217

Size
1,009 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

2nd Floor, Ste 218-219

Size
2,548 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

2nd Floor, Ste 220

Size
1,176 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

2nd Floor, Ste 221

Size
918 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

2nd Floor, Ste 222

Size
926 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

1st Floor, Ste 104

Size 975 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

Office Space

  • Fully Built-Out as Standard Office
  • Office intensive layout
  • Finished Ceilings: 8’
  • Space In Need of Renovation

1st Floor, Ste 106

Size 992 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

office/ Dental/Medical

  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’
  • Space In Need of Renovation

1st Floor, Ste 107 A

Size 727 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

Office

  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’
  • Space In Need of Renovation

1st Floor, Ste 107 B

Size 445 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

Office

  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’

1st Floor, Ste 109

Size 1,054 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’
  • Space In Need of Renovation

1st Floor, Ste 110

Size 568 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

office

  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’

2nd Floor, Ste 212

Size 2,854 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

Beautifully remodeled, ready.

  • Lease rate does not include utilities, property expenses or building services
  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’
  • High End Trophy Space

2nd Floor, Ste 214

Size 1,109 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

1,109 square foot office/medical space along with a mix of private offices available. Complete 2 dental opt plumbing in place. Tenant improvement help available.

  • Fully Built-Out as Standard Medical Space
  • Mostly Open Floor Plan Layout
  • 2 Private Offices
  • Finished Ceilings: 8’
  • Private Restrooms
  • Wheelchair Accessible

2nd Floor, Ste 216

Size 1,129 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

1,129 square foot office/medical space along with a mix of private offices available.

  • Fully Built-Out as Standard Medical Space
  • Mostly Open Floor Plan Layout
  • 2 Private Offices
  • Finished Ceilings: 8’
  • Space is in Excellent Condition
  • Private Restrooms

2nd Floor, Ste 217

Size 1,009 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

1,009 square foot office/medical space along with a mix of private offices available.

  • Fully Built-Out as Dental Office Space
  • Mostly Open Floor Plan Layout
  • 3 Private Offices
  • Finished Ceilings: 8’
  • Space is in Excellent Condition
  • Private Restrooms
  • Wheelchair Accessible

2nd Floor, Ste 218-219

Size 2,548 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

2,548 square foot office/medical space along with a mix of private offices available. Complete 4 dental opts plumbing in place.

  • Fully Built-Out as Dental Office Space
  • Mostly Open Floor Plan Layout
  • 4 Private Offices
  • Finished Ceilings: 8’
  • Space is in Excellent Condition
  • Private Restrooms
  • Wheelchair Accessible

2nd Floor, Ste 220

Size 1,176 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

1,176 square foot office/medical space along with a mix of private offices available.

  • Fully Built-Out as Dental Office Space
  • Mostly Open Floor Plan Layout
  • 3 Private Offices
  • Finished Ceilings: 8’
  • Space is in Excellent Condition
  • Private Restrooms

2nd Floor, Ste 221

Size 918 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

918 square foot office/medical space along with a mix of private offices available.

  • Fully Built-Out as Dental Office Space
  • Mostly Open Floor Plan Layout
  • 2 Private Offices
  • Finished Ceilings: 8’
  • Space is in Excellent Condition
  • Private Restrooms
  • Wheelchair Accessible

2nd Floor, Ste 222

Size 926 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 8’

PROPERTY OVERVIEW

LOS PORTALES CENTER, 2480 Mission Street Nestled in San Francisco’s lively Mission District. Discover one of the neighborhood’s premier destinations for professional office spaces. This well-maintained property offers a range of suites from 445 SF to 2,845 SF, with the flexibility to merge units to fit your growing business needs. Enjoy a professional and welcoming environment ideal for startups, professional services, medical and dental practices, beauty and wellness providers, and various therapy practices. Single occupants and group tenants are both welcome. Property Highlights: • Flexible lease terms at competitive rates • Secure on-site parking garage with convenient tenant access • Easy access to public transportation • Surrounded by top local amenities, including Grand Coffee, Lolinda, and Foreign Cinema • Open Monday through Saturday Grow your business in a space that combines comfort, convenience, and professionalism—perfectly positioned in one of the city’s most vibrant neighborhoods.

  • 24 Hour Access
  • Wheelchair Accessible
  • Roof Terrace

PROPERTY FACTS

Building Type
Office
Year Built/Renovated
1972/2024
Building Height
3 Stories
Building Size
36,969 SF
Building Class
B
Typical Floor Size
12,323 SF
Unfinished Ceiling Height
10’
Parking
Surface Tandem Parking
24 Covered Parking Spaces at $300/month
Covered Tandem Parking
Reserved Parking
Walk Score®
Walker's Paradise (99)
Transit Score®
Excellent Transit (89)
Bike Score®
Biker's Paradise (99)
What is a Walk Score®, Transit Score® & Bike Score®?
Walk Score® measures the walkability of any address.
Transit Score® measures access to public transit.
Bike Score® measures bikeability of a location.
What is a Walk Score®
, Transit Score® & Bike Score?
Walk Score® measures the walkability
of any address. Transit Score®
measures access to public transit. Bike Score®
measures bikeability of a location.®
  • Listing ID: 36812298

  • Date on Market: 12/21/2025

  • Last Updated:

  • Address: 2480 Mission St, San Francisco, CA 94110

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