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All Available Spaces(5)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • 1st Floor, Ste 160A
  • 800 SF
  • 2 Years
  • $13.00 /SF/YR $1.08 /SF/MO $10,400 /YR $866.67 /MO
  • Retail
  • -
  • Now
  • Lease rate does not include utilities, property expenses or building services
  • Space is in Excellent Condition
  • 1st Floor, Ste Building C
  • 4,590 SF
  • 2-4 Years
  • $8.75 /SF/YR $0.73 /SF/MO $40,163 /YR $3,347 /MO
  • Office/Medical
  • -
  • Now

Prime 4,590 SF Commercial Space | Retail, Office & Restaurant Versatile ±4,590 SF commercial space with the flexibility to accommodate a wide range of uses. The property is well suited for retail, office, medical, professional services, or restaurant use, with 400-amp, three-phase electrical service providing the power capacity needed for more demanding commercial operations. Highlights ±4,590 SF Available 400-Amp Electrical Service Three-Phase Power Flexible Retail, Office & Commercial Layout Potential for Restaurant Use Ample Parking Excellent Opportunity for a Business Looking for Room to Grow Ideal For Restaurants & Food Service Retail Medical & Healthcare Professional Offices Showrooms Service Businesses Fitness & Wellness Specialty Commercial Uses A rare combination of size, flexibility, and substantial electrical capacity—making this space suitable for everything from a professional office to a full-service restaurant.

  • Lease rate does not include utilities, property expenses or building services
  • Space is in Excellent Condition
  • Fits 12 - 37 People
  • 1st Floor, Ste C-101
  • 2,065 SF
  • 2 Years
  • $10.50 /SF/YR $0.88 /SF/MO $21,683 /YR $1,807 /MO
  • Office/Medical
  • -
  • Now

Prime Commercial Office Space Near Downtown Lake City Position your business in one of Lake City's most visible and convenient commercial corridors. Located at 260 S Marion Avenue, this 2,065 SF professional office space offers excellent accessibility, strong traffic exposure, and a flexible layout suitable for a variety of uses. The property benefits from approximately 35,500 vehicles per day (AADT) and is located less than 3 miles from the I-75 / US-90 interchange, providing easy access for clients, patients, and employees. Downtown Lake City, major medical facilities, restaurants, and retail services are all nearby. Ideal Uses Salon Suites Medical or Dental Office Therapy or Counseling Practice Professional Office Wellness Services Retail or Service Businesses Space Features Reception / Waiting Room Receptionist Area Six (6) Private Offices Two (2) Restrooms Dedicated Storage Room Additional Storage Areas Flexible Floor Plan Ample On-Site Parking Property Highlights ±2,065 SF Available Lease Rate: $2,200/Month High-Visibility Location Strong Traffic Counts (35,500 AADT) Less Than 3 Miles to I-75 & US-90 Close to Downtown Lake City and Medical District Move-In Ready Layout This is an excellent opportunity for a growing business seeking an affordable, well-located office space with an established professional layout. Contact for additional information or to schedule a private tour.

  • Lease rate does not include utilities, property expenses or building services
  • 6 Conference Rooms
  • Fits 1 - 20 People
  • Space is in Excellent Condition
  • 1st Floor, Ste C-101-A
  • 2,785 SF
  • 2 Years
  • $10.50 /SF/YR $0.88 /SF/MO $29,243 /YR $2,437 /MO
  • Office/Medical
  • -
  • Now

### 2,785 SF Commercial Space Available in Lake City, FL **Prime Commercial Opportunity in Lake City!** Approximately **2,785 square feet of versatile commercial space** available in a convenient Lake City location. The property offers an excellent opportunity for a wide range of businesses looking for affordable, functional commercial space. Potential uses include **restaurants, cafés, coffee shops, bakeries, takeout and food-service businesses, medical and healthcare offices, professional offices, salons and beauty businesses, retail, specialty services, and more**, subject to applicable zoning and permitting requirements. **Property Highlights:** * Approximately **2,785 SF** * **Commercial General (CG) zoning** * Flexible space suitable for a variety of commercial uses * Potential for **restaurant, café, coffee shop, and food-service concepts** * Ample parking * Convenient Lake City location * Excellent opportunity for an established business or new venture * Affordable commercial space in the Lake City market Whether you're opening a **new restaurant or café, expanding a healthcare practice, launching a retail business, or relocating an established company**, this versatile 2,785 SF space provides an excellent opportunity to establish your business in Lake City. **Contact us today to schedule a tour or discuss your business needs.**

  • Lease rate does not include utilities, property expenses or building services
  • 6 Conference Rooms
  • Fits 7 - 23 People
  • Space is in Excellent Condition
  • 1st Floor, Ste C-101B
  • 500 SF
  • 2 Years
  • $16.50 /SF/YR $1.38 /SF/MO $8,250 /YR $687.50 /MO
  • Retail
  • -
  • Now

Copilot said: Space Description (Suite Sizes from ±500 SF to 2,065 SF) Flexible office suites available in a highly visible professional office building located at 260 S Marion Avenue, Lake City, Florida. Spaces can be leased from approximately 500 SF up to 2,065 SF, making the property ideal for individual professionals, therapists, counselors, attorneys, medical users, wellness providers, insurance agencies, and other office-based businesses. Tenants benefit from a professional office environment featuring a reception/waiting area, multiple private offices, restrooms, storage areas, and convenient on-site parking. The property is strategically located near Downtown Lake City with excellent accessibility and strong exposure, less than three miles from the I-75/US-90 interchange. Highlights Suites available from ±500 SF to ±2,065 SF Flexible floor plans and lease options Private office layouts available Shared reception/waiting area potential On-site parking High-visibility location Near Downtown Lake City Close to major medical facilities, restaurants, and retail Easy access to I-75 and US-90 Ideal Uses Medical & Healthcare Counseling & Therapy Professional Offices Salon Suites Insurance & Financial Services Real Estate Offices Wellness & Personal Services Perfect opportunity for businesses seeking a professional, affordable office location with flexible suite sizes and room to grow.

  • Lease rate does not include utilities, property expenses or building services
  • Space is in Excellent Condition
Space Size Term Rental Rate Space Use Build-Out Available
1st Floor, Ste 160A 800 SF 2 Years $13.00 /SF/YR $1.08 /SF/MO $10,400 /YR $866.67 /MO Retail - Now
1st Floor, Ste Building C 4,590 SF 2-4 Years $8.75 /SF/YR $0.73 /SF/MO $40,163 /YR $3,347 /MO Office/Medical - Now
1st Floor, Ste C-101 2,065 SF 2 Years $10.50 /SF/YR $0.88 /SF/MO $21,683 /YR $1,807 /MO Office/Medical - Now
1st Floor, Ste C-101-A 2,785 SF 2 Years $10.50 /SF/YR $0.88 /SF/MO $29,243 /YR $2,437 /MO Office/Medical - Now
1st Floor, Ste C-101B 500 SF 2 Years $16.50 /SF/YR $1.38 /SF/MO $8,250 /YR $687.50 /MO Retail - Now

1st Floor, Ste 160A

Size
800 SF
Term
2 Years
Rental Rate
$13.00 /SF/YR $1.08 /SF/MO $10,400 /YR $866.67 /MO
Space Use
Retail
Build-Out
-
Available
Now

1st Floor, Ste Building C

Size
4,590 SF
Term
2-4 Years
Rental Rate
$8.75 /SF/YR $0.73 /SF/MO $40,163 /YR $3,347 /MO
Space Use
Office/Medical
Build-Out
-
Available
Now

1st Floor, Ste C-101

Size
2,065 SF
Term
2 Years
Rental Rate
$10.50 /SF/YR $0.88 /SF/MO $21,683 /YR $1,807 /MO
Space Use
Office/Medical
Build-Out
-
Available
Now

1st Floor, Ste C-101-A

Size
2,785 SF
Term
2 Years
Rental Rate
$10.50 /SF/YR $0.88 /SF/MO $29,243 /YR $2,437 /MO
Space Use
Office/Medical
Build-Out
-
Available
Now

1st Floor, Ste C-101B

Size
500 SF
Term
2 Years
Rental Rate
$16.50 /SF/YR $1.38 /SF/MO $8,250 /YR $687.50 /MO
Space Use
Retail
Build-Out
-
Available
Now

1st Floor, Ste 160A

Size 800 SF
Term 2 Years
Rental Rate $13.00 /SF/YR
Space Use Retail
Build-Out -
Available Now

  • Lease rate does not include utilities, property expenses or building services
  • Space is in Excellent Condition

1st Floor, Ste Building C

Size 4,590 SF
Term 2-4 Years
Rental Rate $8.75 /SF/YR
Space Use Office/Medical
Build-Out -
Available Now

Prime 4,590 SF Commercial Space | Retail, Office & Restaurant Versatile ±4,590 SF commercial space with the flexibility to accommodate a wide range of uses. The property is well suited for retail, office, medical, professional services, or restaurant use, with 400-amp, three-phase electrical service providing the power capacity needed for more demanding commercial operations. Highlights ±4,590 SF Available 400-Amp Electrical Service Three-Phase Power Flexible Retail, Office & Commercial Layout Potential for Restaurant Use Ample Parking Excellent Opportunity for a Business Looking for Room to Grow Ideal For Restaurants & Food Service Retail Medical & Healthcare Professional Offices Showrooms Service Businesses Fitness & Wellness Specialty Commercial Uses A rare combination of size, flexibility, and substantial electrical capacity—making this space suitable for everything from a professional office to a full-service restaurant.

  • Lease rate does not include utilities, property expenses or building services
  • Fits 12 - 37 People
  • Space is in Excellent Condition

1st Floor, Ste C-101

Size 2,065 SF
Term 2 Years
Rental Rate $10.50 /SF/YR
Space Use Office/Medical
Build-Out -
Available Now

Prime Commercial Office Space Near Downtown Lake City Position your business in one of Lake City's most visible and convenient commercial corridors. Located at 260 S Marion Avenue, this 2,065 SF professional office space offers excellent accessibility, strong traffic exposure, and a flexible layout suitable for a variety of uses. The property benefits from approximately 35,500 vehicles per day (AADT) and is located less than 3 miles from the I-75 / US-90 interchange, providing easy access for clients, patients, and employees. Downtown Lake City, major medical facilities, restaurants, and retail services are all nearby. Ideal Uses Salon Suites Medical or Dental Office Therapy or Counseling Practice Professional Office Wellness Services Retail or Service Businesses Space Features Reception / Waiting Room Receptionist Area Six (6) Private Offices Two (2) Restrooms Dedicated Storage Room Additional Storage Areas Flexible Floor Plan Ample On-Site Parking Property Highlights ±2,065 SF Available Lease Rate: $2,200/Month High-Visibility Location Strong Traffic Counts (35,500 AADT) Less Than 3 Miles to I-75 & US-90 Close to Downtown Lake City and Medical District Move-In Ready Layout This is an excellent opportunity for a growing business seeking an affordable, well-located office space with an established professional layout. Contact for additional information or to schedule a private tour.

  • Lease rate does not include utilities, property expenses or building services
  • Fits 1 - 20 People
  • 6 Conference Rooms
  • Space is in Excellent Condition

1st Floor, Ste C-101-A

Size 2,785 SF
Term 2 Years
Rental Rate $10.50 /SF/YR
Space Use Office/Medical
Build-Out -
Available Now

### 2,785 SF Commercial Space Available in Lake City, FL **Prime Commercial Opportunity in Lake City!** Approximately **2,785 square feet of versatile commercial space** available in a convenient Lake City location. The property offers an excellent opportunity for a wide range of businesses looking for affordable, functional commercial space. Potential uses include **restaurants, cafés, coffee shops, bakeries, takeout and food-service businesses, medical and healthcare offices, professional offices, salons and beauty businesses, retail, specialty services, and more**, subject to applicable zoning and permitting requirements. **Property Highlights:** * Approximately **2,785 SF** * **Commercial General (CG) zoning** * Flexible space suitable for a variety of commercial uses * Potential for **restaurant, café, coffee shop, and food-service concepts** * Ample parking * Convenient Lake City location * Excellent opportunity for an established business or new venture * Affordable commercial space in the Lake City market Whether you're opening a **new restaurant or café, expanding a healthcare practice, launching a retail business, or relocating an established company**, this versatile 2,785 SF space provides an excellent opportunity to establish your business in Lake City. **Contact us today to schedule a tour or discuss your business needs.**

  • Lease rate does not include utilities, property expenses or building services
  • Fits 7 - 23 People
  • 6 Conference Rooms
  • Space is in Excellent Condition

1st Floor, Ste C-101B

Size 500 SF
Term 2 Years
Rental Rate $16.50 /SF/YR
Space Use Retail
Build-Out -
Available Now

Copilot said: Space Description (Suite Sizes from ±500 SF to 2,065 SF) Flexible office suites available in a highly visible professional office building located at 260 S Marion Avenue, Lake City, Florida. Spaces can be leased from approximately 500 SF up to 2,065 SF, making the property ideal for individual professionals, therapists, counselors, attorneys, medical users, wellness providers, insurance agencies, and other office-based businesses. Tenants benefit from a professional office environment featuring a reception/waiting area, multiple private offices, restrooms, storage areas, and convenient on-site parking. The property is strategically located near Downtown Lake City with excellent accessibility and strong exposure, less than three miles from the I-75/US-90 interchange. Highlights Suites available from ±500 SF to ±2,065 SF Flexible floor plans and lease options Private office layouts available Shared reception/waiting area potential On-site parking High-visibility location Near Downtown Lake City Close to major medical facilities, restaurants, and retail Easy access to I-75 and US-90 Ideal Uses Medical & Healthcare Counseling & Therapy Professional Offices Salon Suites Insurance & Financial Services Real Estate Offices Wellness & Personal Services Perfect opportunity for businesses seeking a professional, affordable office location with flexible suite sizes and room to grow.

  • Lease rate does not include utilities, property expenses or building services
  • Space is in Excellent Condition

Property Overview

Available Spaces from 500–4,800 SF | Office, Medical, Beauty, Retail & Restaurant Looking for commercial space in Lake City? We have spaces ranging from approximately 500 SF to 4,800 SF, with options to accommodate businesses of all sizes. Located on Marion Avenue (US-441) near downtown and the historic district, these flexible commercial spaces can be configured for a wide variety of businesses, including office, beauty, medical, retail, and restaurant uses. Available Space Options ±500 SF to ±4,800 SF Multiple suite sizes available Flexible layouts and build-out potential High-visibility Marion Avenue location Customer and client parking available Spaces suitable for both established businesses and new startups Larger spaces may offer substantial electrical capacity, including 400-amp, three-phase power Ideal For Office & Professional Services Medical & Healthcare Beauty Salons & Barber Shops Nail, Lash & Esthetics Studios Retail & Specialty Shops Restaurants & Food Service Fitness & Wellness Showrooms Therapy & Chiropractic Insurance, Real Estate, Accounting & Tax Services Location Advantage Located along Marion Avenue (US-441), one of Lake City's primary commercial corridors, with strong visibility and convenient access for both local customers and pass-through traffic. Whether you need a 500 SF startup space or a 4,800 SF location for an established business, we have options to fit your needs.

  • 24 Hour Access
  • Courtyard
  • Signage
  • Air Conditioning

Property Facts

Building Type
Office
Year Built
1975
Building Height
1 Story
Building Size
15,577 SF
Building Class
C
Typical Floor Size
15,577 SF
Parking
75 Surface Parking Spaces

Select Tenants

  • Floor
  • Tenant Name
  • Industry
  • 1st
  • Gateway Judicial Service
  • Health Care and Social Assistance
  • 1st
  • Itm
  • -
  • 1st
  • Lake City Laboratory
  • Health Care and Social Assistance
  • 1st
  • Lincare
  • Wholesaler
  • 1st
  • Northeast Florida Safety Council
  • Educational Services
  • 1st
  • Oasis Of Hope
  • Health Care and Social Assistance
Fairly walkable
50/100
Exceptionally drivable
100/100
Fairly bikeable
40/100
  • Listing ID: 40825747

  • Date on Market: 9/5/2026

  • Last Updated:

  • Address: 260 S Marion Ave, Lake City, FL 32025

Contact the Leasing Agent

260 S Marion Ave

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