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301 S Main St 9,640 SF of Flex Space Available in Harrisonburg, VA 22801

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All Available Space(1)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Condition
  • Available
  • -
  • 9,640 SF
  • Negotiable
  • $20.00 /SF/YR $1.67 /SF/MO $192,800 /YR $16,067 /MO
  • Flex
  • Partial Build-Out
  • April 07, 2026

This historic building was built in 1850’s and used as a hospital for civil war wounded soldiers. It has been kept really well preserved. This is a Mixed Use building for any kind of businesses or residences. Total 10,500 square feet including attic which has a phenomenal view. Basement was used as office space approximately 3500 square feet. Even though it is basement from the front of the house, it is the first floor from the backside. There are three entrances from ground level. Currently there are many office spaces which can be used as lawyers office, or knocked down and converted to Brewery club. First floor is large open area with 3500 square feet. This space can be used as a restaurant or retail. There are so many people in downtown who can benefit from all kinds of businesses. Maybe, a consignment shop or computer repair? You name the business. Second floor has 10 feet ceiling with great open spaces. About 3000 square feet. This space can be utilized as an office spaces, medical practices, or massage spa, maybe. It is your call. Attic space is very unique, about 800 square feet with four windows facing North, South, West and East. We can convert into a living quarters looking out the window to see the beautiful downtown Harrisonburg. Just being involved with this historic building alone has a nostalgic healing. Price above is just for the attraction for you to read. If it is not for you, you can find someone you know who might be seriously interested. There is also leasehold improvement allowances available. Federal, State and Local government welcomes you to revitalize this amazing historic building. Please come join us and make this your next dream house or business!!

  • Lease rate does not include utilities, property expenses or building services
  • Venerable historic landmark building
Space Size Term Rental Rate Space Use Condition Available
- 9,640 SF Negotiable $20.00 /SF/YR $1.67 /SF/MO $192,800 /YR $16,067 /MO Flex Partial Build-Out April 07, 2026

-

Size
9,640 SF
Term
Negotiable
Rental Rate
$20.00 /SF/YR $1.67 /SF/MO $192,800 /YR $16,067 /MO
Space Use
Flex
Condition
Partial Build-Out
Available
April 07, 2026

-

Size 9,640 SF
Term Negotiable
Rental Rate $20.00 /SF/YR
Space Use Flex
Condition Partial Build-Out
Available April 07, 2026

This historic building was built in 1850’s and used as a hospital for civil war wounded soldiers. It has been kept really well preserved. This is a Mixed Use building for any kind of businesses or residences. Total 10,500 square feet including attic which has a phenomenal view. Basement was used as office space approximately 3500 square feet. Even though it is basement from the front of the house, it is the first floor from the backside. There are three entrances from ground level. Currently there are many office spaces which can be used as lawyers office, or knocked down and converted to Brewery club. First floor is large open area with 3500 square feet. This space can be used as a restaurant or retail. There are so many people in downtown who can benefit from all kinds of businesses. Maybe, a consignment shop or computer repair? You name the business. Second floor has 10 feet ceiling with great open spaces. About 3000 square feet. This space can be utilized as an office spaces, medical practices, or massage spa, maybe. It is your call. Attic space is very unique, about 800 square feet with four windows facing North, South, West and East. We can convert into a living quarters looking out the window to see the beautiful downtown Harrisonburg. Just being involved with this historic building alone has a nostalgic healing. Price above is just for the attraction for you to read. If it is not for you, you can find someone you know who might be seriously interested. There is also leasehold improvement allowances available. Federal, State and Local government welcomes you to revitalize this amazing historic building. Please come join us and make this your next dream house or business!!

  • Lease rate does not include utilities, property expenses or building services
  • Venerable historic landmark building

Property Overview

This historic building was built in 1850’s and used as a hospital for civil war wounded soldiers. It has been kept really well preserved. This is a Mixed Use building for any kind of businesses or residences. Total 10,500 square feet including attic which has a phenomenal view. Basement was used as office space approximately 3500 square feet. Even though it is basement from the front of the house, it is the first floor from the backside. There are three entrances from ground level. Currently there are many office spaces which can be used as lawyers office, or knocked down and converted to Brewery club. First floor is large open area with 3500 square feet. This space can be used as a restaurant or retail. There are so many people in downtown who can benefit from all kinds of businesses. Maybe, a consignment shop or computer repair? You name the business. Second floor has 10 feet ceiling with great open spaces. About 3000 square feet. This space can be utilized as an office spaces, medical practices, or massage spa, maybe. It is your call. Attic space is very unique, about 800 square feet with four windows facing North, South, West and East. We can convert into a living quarters looking out the window to see the beautiful downtown Harrisonburg. Just being involved with this historic building alone has a nostalgic healing. Price above is just for the attraction for you to read. If it is not for you, you can find someone you know who might be seriously interested. There is also leasehold improvement allowances available. Federal, State and Local government welcomes you to revitalize this amazing historic building. Please come join us and make this your next dream house or business!!

Property Facts

Building Size
9,640 SF
Year Built
1856
Zoning
B1 - Quadrant 4 NS S Main St Commercial and mixed use.
Walk Score®
Very Walkable (88)
What is a Walk Score®, Transit Score® & Bike Score®?
Walk Score® measures the walkability of any address.
Transit Score® measures access to public transit.
Bike Score® measures bikeability of a location.
What is a Walk Score®
, Transit Score® & Bike Score?
Walk Score® measures the walkability
of any address. Transit Score®
measures access to public transit. Bike Score®
measures bikeability of a location.®
  • Listing ID: 39368447

  • Date on Market: 2/8/2026

  • Last Updated:

  • Address: 301 S Main St, Harrisonburg, VA 22801

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