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Highlights

  • Flexible Office / Medical Use.
  • Suite 320: Third Floor Space Comprised of 578 Sq. Ft. and Multiple Private Rooms.
  • Building Has Elevator Service and On-Site Parking Available.
  • Suite 400: Penthouse Unit Comprised of 2,487 Sq. Ft. and Multiple Private Rooms.
  • Building Has an Existing Tenant Roster of Office, Medical, and Professional Services.
  • Ideally Located in SF's Bustling West Portal District and Directly on West Portal Ave.

All Available Spaces(2)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • 3rd Floor, Ste 320
  • 578 SF
  • Negotiable
  • $60.00 /SF/YR $5.00 /SF/MO $34,680 /YR $2,890 /MO
  • Office/Medical
  • -
  • Now

This is an exceptional opportunity for your new or expanding office needs located in the heart of West Portal, one of San Francisco’s most affluent and established commercial corridors. The building is currently home to a strong roster of complementary tenants, including dental practices, physicians, and professional office users, creating a synergistic atmosphere and ideal for many uses. Suite 320 – The 3rd floor space is approximately 578 Sq. Ft., with 3 private rooms, a dedicated kitchen, and in updated condition with access to the building’s common area restroom. The building is professionally managed and well-maintained showing clear pride of ownership and offers an ideal environment for medical or professional office users seeking a highly visible and accessible location. Rear parking adds further convenience for tenants and visitors alike.

  • Lease rate does not include utilities, property expenses or building services
  • Approximately 578 Sq. Ft.
  • 3 Private Rooms w/Exclusive Use Kitchen.
  • Space is in Excellent Condition
  • Suite is in Updated/Remodeled Condition.
  • Access to Common Area Restroom.
  • 4th Floor, Ste 400
  • 2,487 SF
  • Negotiable
  • $36.00 /SF/YR $3.00 /SF/MO $89,532 /YR $7,461 /MO
  • Office
  • Full Build-Out
  • Now

This is an exceptional opportunity for your new or expanding office needs located in the heart of West Portal, one of San Francisco’s most affluent and established commercial corridors. The building is currently home to a strong roster of complementary tenants, including dental practices, physicians, and professional office users, creating a synergistic atmosphere and ideal for many uses. Suite 400 - The top floor space is approximately 2,487 Sq. Ft., featuring a large open concept center, with multiple private rooms, private restroom, and lots of natural light. The building is professionally managed and well-maintained showing clear pride of ownership and offers an ideal environment for medical or professional office users seeking a highly visible and accessible location. Rear parking adds further convenience for tenants and visitors alike.

  • Lease rate does not include utilities, property expenses or building services
  • Approximately 2,487 Sq. Ft.
  • Multiple Private Rooms and Private Restrooms.
  • Fully Built-Out as Standard Office
  • Large Open Concept w/Lots of Natural Light.
  • Penthouse Level w/Direct Elevator Access.
Space Size Term Rental Rate Space Use Build-Out Available
3rd Floor, Ste 320 578 SF Negotiable $60.00 /SF/YR $5.00 /SF/MO $34,680 /YR $2,890 /MO Office/Medical - Now
4th Floor, Ste 400 2,487 SF Negotiable $36.00 /SF/YR $3.00 /SF/MO $89,532 /YR $7,461 /MO Office Full Build-Out Now

3rd Floor, Ste 320

Size
578 SF
Term
Negotiable
Rental Rate
$60.00 /SF/YR $5.00 /SF/MO $34,680 /YR $2,890 /MO
Space Use
Office/Medical
Build-Out
-
Available
Now

4th Floor, Ste 400

Size
2,487 SF
Term
Negotiable
Rental Rate
$36.00 /SF/YR $3.00 /SF/MO $89,532 /YR $7,461 /MO
Space Use
Office
Build-Out
Full Build-Out
Available
Now

3rd Floor, Ste 320

Size 578 SF
Term Negotiable
Rental Rate $60.00 /SF/YR
Space Use Office/Medical
Build-Out -
Available Now

This is an exceptional opportunity for your new or expanding office needs located in the heart of West Portal, one of San Francisco’s most affluent and established commercial corridors. The building is currently home to a strong roster of complementary tenants, including dental practices, physicians, and professional office users, creating a synergistic atmosphere and ideal for many uses. Suite 320 – The 3rd floor space is approximately 578 Sq. Ft., with 3 private rooms, a dedicated kitchen, and in updated condition with access to the building’s common area restroom. The building is professionally managed and well-maintained showing clear pride of ownership and offers an ideal environment for medical or professional office users seeking a highly visible and accessible location. Rear parking adds further convenience for tenants and visitors alike.

  • Lease rate does not include utilities, property expenses or building services
  • Space is in Excellent Condition
  • Approximately 578 Sq. Ft.
  • Suite is in Updated/Remodeled Condition.
  • 3 Private Rooms w/Exclusive Use Kitchen.
  • Access to Common Area Restroom.

4th Floor, Ste 400

Size 2,487 SF
Term Negotiable
Rental Rate $36.00 /SF/YR
Space Use Office
Build-Out Full Build-Out
Available Now

This is an exceptional opportunity for your new or expanding office needs located in the heart of West Portal, one of San Francisco’s most affluent and established commercial corridors. The building is currently home to a strong roster of complementary tenants, including dental practices, physicians, and professional office users, creating a synergistic atmosphere and ideal for many uses. Suite 400 - The top floor space is approximately 2,487 Sq. Ft., featuring a large open concept center, with multiple private rooms, private restroom, and lots of natural light. The building is professionally managed and well-maintained showing clear pride of ownership and offers an ideal environment for medical or professional office users seeking a highly visible and accessible location. Rear parking adds further convenience for tenants and visitors alike.

  • Lease rate does not include utilities, property expenses or building services
  • Fully Built-Out as Standard Office
  • Approximately 2,487 Sq. Ft.
  • Large Open Concept w/Lots of Natural Light.
  • Multiple Private Rooms and Private Restrooms.
  • Penthouse Level w/Direct Elevator Access.

Property Overview

This is an exceptional opportunity for your new or expanding office needs located in the heart of West Portal, one of San Francisco’s most affluent and established commercial corridors. The building is currently home to a strong roster of complementary tenants, including dental practices, physicians, and professional office users, creating a synergistic atmosphere and ideal for many uses. Two suites are currently available: Suite 400 - The top floor space is approximately 2,487 Sq. Ft., featuring a large open concept center, with multiple private rooms, private restroom, and lots of natural light. Suite 320 – The 3rd floor space is approximately 578 Sq. Ft., with 3 private rooms, a dedicated kitchen, and in updated condition with access to the building’s common area restroom. The building is professionally managed and well-maintained showing clear pride of ownership and offers an ideal environment for medical or professional office users seeking a highly visible and accessible location. Rear parking adds further convenience for tenants and visitors alike. West Portal is one of San Francisco’s most established and neighborhood-oriented commercial corridors. Known for its village-like atmosphere, tree-lined streets, and strong local identity, the district offers a vibrant mix of longtime retailers, restaurants, cafés, and professional services that cater to a loyal residential customer base. The area benefits from consistent foot traffic driven by both neighborhood residents and commuters utilizing the nearby Muni Metro station, providing direct connectivity to Downtown San Francisco and surrounding neighborhoods. Surrounded by well-maintained residential homes and affluent residential enclaves, West Portal offers a unique balance of urban accessibility and neighborhood charm. The district’s pedestrian-friendly environment, strong community presence, and limited retail vacancy have helped maintain its appeal as a desirable destination for both local businesses and national tenants seeking visibility within one of San Francisco’s most stable and affluent submarkets.

  • 24 Hour Access
  • Metro/Subway
  • Signage
  • Direct Elevator Exposure
  • Wi-Fi

Property Facts

Building Type
Office
Year Built
1966
Building Height
4 Stories
Building Size
11,113 SF
Building Class
B
Typical Floor Size
2,778 SF
Unfinished Ceiling Height
12’
Parking
17 Surface Parking Spaces
Covered Parking

Select Tenants

  • Floor
  • Tenant Name
  • Industry
  • 1st
  • Asher Student Foundation
  • Professional, Scientific, and Technical Services
  • 1st
  • Daniel L.James, Physical Therapy, Inc.
  • Health Care and Social Assistance
  • 1st
  • Edward Jones
  • Finance and Insurance
  • 2nd
  • Empowered Healthcare Community
  • Health Care and Social Assistance
  • 2nd
  • Firefly Orthodontics
  • Health Care and Social Assistance
  • 1st
  • Nelson Law Group PLLC
  • Professional, Scientific, and Technical Services
  • 3rd
  • Practice Sf
  • Health Care and Social Assistance
  • 1st
  • San Francisco Preventive Medical Group
  • Health Care and Social Assistance
  • 1st
  • Taft Haus, Llc
  • Public Administration
  • 1st
  • West Portal Physical Therapy
  • Health Care and Social Assistance
Very walkable
80/100
Moderately drivable
70/100
Exceptional public transit
100/100
Moderately bikeable
60/100
  • Listing ID: 40483404

  • Date on Market: 5/11/2026

  • Last Updated:

  • Address: 345 W Portal Ave, San Francisco, CA 94127

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