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Park Highlights

  • Elevator served & Operable windows
  • Business park setting with large shared parking lot
  • Central San Diego Location / Kearny Mesa
  • Internal Atrium allowing natural light in common areas
  • 0.19 Miles from I-15 off and on ramps
  • Walking distance to retail centers

Park Facts

Total Space Available 3,127 SF
Park Type Office Park
Features
24 Hour Access
  • Atrium, Tenant Controlled HVAC, Air Conditioning

All Available Spaces(3)

Display Rental Rate as

Ruffin Business Center
3645 Ruffin Rd
821 - 2,160 SF | Upon Request Upon Request Upon Request Upon Request Upon Request Upon Request | View Building Details
Building Type/Class
Office/B
Year Built
1986
Building Size
21,168 SF
Building Height
3 Stories
Typical Floor Size
7,056 SF
  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • 2nd Floor, Ste 205
  • 821 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • July 13, 2026

Located on second Floor Operable windows providing fresh airflow Open office/bullpen area ideal for collaborative workspace or reception setup Two perimeter offices of varying sizes Individual HVAC control with dedicated thermostat

  • Listed rate may not include certain utilities, building services and property expenses
  • Central Air Conditioning
  • Operable Windows
  • 2 Private Offices
  • Drop Ceilings
  • Offices on Window Line
  • 3rd Floor, Ste 315
  • 1,339 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now

Located on Third floor with Sweeping views Corner suite location with numerous windows and abundant natural light Operable windows providing fresh airflow Double-door entrance Dedicated waiting/reception area Six private offices Sink and cabinetry in place with room for full kitchenette expansion if necessary Two interior offices were previously combined as a larger conference room and feature a large interior window for added light Large rear room/office with secondary exit to common area restrooms and elevator access Dimmable LED lighting throughout Individual HVAC control with dedicated thermostat Abundant electrical outlets throughout each office Dedicated TI/storage closet Faux wood flooring throughout

  • Fully Built-Out as Standard Medical Space
  • Space is in Excellent Condition
  • Mostly Open Floor Plan Layout
Space Size Term Rental Rate Space Use Build-Out Available
2nd Floor, Ste 205 821 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - July 13, 2026
3rd Floor, Ste 315 1,339 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
Ruffin Business Center
3645 Ruffin Rd
821 - 2,160 SF | Upon Request Upon Request Upon Request Upon Request Upon Request Upon Request | View Building Details
Building Type/Class
Office/B
Year Built
1986
Building Size
21,168 SF
Building Height
3 Stories
Typical Floor Size
7,056 SF

3645 Ruffin Rd - 2nd Floor - Ste 205

Size
821 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
-
Available
July 13, 2026

3645 Ruffin Rd - 3rd Floor - Ste 315

Size
1,339 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Build-Out
Full Build-Out
Available
Now
Ruffin Business Center
3655 Ruffin Rd
967 SF | Upon Request Upon Request Upon Request Upon Request Upon Request Upon Request | View Building Details
Building Type/Class
Office/B
Year Built
1986
Building Size
19,637 SF
Building Height
3 Stories
Typical Floor Size
6,833 SF
  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • 3rd Floor, Ste 360
  • 967 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now

Located on Third floor with Sweeping views Operable windows providing fresh airflow Ready to Lease with newer paint and commercial carpet flooring Open office/bullpen area with flexible workspace configuration Two offices positioned on the window line Corner office or conferenc room with windows along two sides Additional room suitable for storage, IT, or a small private office Individual HVAC control with dedicated thermostat Suite entry located near elevator and common area restrooms

  • Listed rate may not include certain utilities, building services and property expenses
  • Fully Carpeted
  • Natural Light
  • Central Air Conditioning
  • Drop Ceilings
  • Atrium
Space Size Term Rental Rate Space Use Build-Out Available
3rd Floor, Ste 360 967 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
Ruffin Business Center
3655 Ruffin Rd
967 SF | Upon Request Upon Request Upon Request Upon Request Upon Request Upon Request | View Building Details
Building Type/Class
Office/B
Year Built
1986
Building Size
19,637 SF
Building Height
3 Stories
Typical Floor Size
6,833 SF

3655 Ruffin Rd - 3rd Floor - Ste 360

Size
967 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
-
Available
Now

3645 Ruffin Rd - 2nd Floor - Ste 205

Size 821 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out -
Available July 13, 2026

Located on second Floor Operable windows providing fresh airflow Open office/bullpen area ideal for collaborative workspace or reception setup Two perimeter offices of varying sizes Individual HVAC control with dedicated thermostat

  • Listed rate may not include certain utilities, building services and property expenses
  • 2 Private Offices
  • Central Air Conditioning
  • Drop Ceilings
  • Operable Windows
  • Offices on Window Line

3645 Ruffin Rd - 3rd Floor - Ste 315

Size 1,339 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Build-Out Full Build-Out
Available Now

Located on Third floor with Sweeping views Corner suite location with numerous windows and abundant natural light Operable windows providing fresh airflow Double-door entrance Dedicated waiting/reception area Six private offices Sink and cabinetry in place with room for full kitchenette expansion if necessary Two interior offices were previously combined as a larger conference room and feature a large interior window for added light Large rear room/office with secondary exit to common area restrooms and elevator access Dimmable LED lighting throughout Individual HVAC control with dedicated thermostat Abundant electrical outlets throughout each office Dedicated TI/storage closet Faux wood flooring throughout

  • Fully Built-Out as Standard Medical Space
  • Mostly Open Floor Plan Layout
  • Space is in Excellent Condition

3655 Ruffin Rd - 3rd Floor - Ste 360

Size 967 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out -
Available Now

Located on Third floor with Sweeping views Operable windows providing fresh airflow Ready to Lease with newer paint and commercial carpet flooring Open office/bullpen area with flexible workspace configuration Two offices positioned on the window line Corner office or conferenc room with windows along two sides Additional room suitable for storage, IT, or a small private office Individual HVAC control with dedicated thermostat Suite entry located near elevator and common area restrooms

  • Listed rate may not include certain utilities, building services and property expenses
  • Central Air Conditioning
  • Fully Carpeted
  • Drop Ceilings
  • Natural Light
  • Atrium

Park Overview

Located in Kearny Mesa, one of San Diego’s most established business and commercial districts, this two-building property offers exceptional accessibility and connectivity to major transportation corridors including Interstate 15, Interstate 805, and State Route 163. Positioned near a prominent intersection (Ruffin Rd. & Aero Dr.), the property provides convenient access for employees, clients, and visitors throughout San Diego County. The surrounding area features a strong mix of office, industrial, retail, and dining amenities, making it an ideal business environment for a wide range of professional users. Nearby retailers, restaurants, and service providers contribute to a highly convenient and amenity-rich location within one of Central San Diego’s most active commercial hubs.

  • 24 Hour Access
  • Atrium
  • Tenant Controlled HVAC
  • Air Conditioning
Moderately walkable
70/100
Exceptionally drivable
100/100
Limited public transit
30/100
Fairly bikeable
50/100
  • Listing ID: 40853212

  • Date on Market: 7/6/2026

  • Last Updated:

  • Address: 3665 Ruffin Rd, San Diego, CA 92123

Contact the Leasing Agent

Ruffin Business Center | San Diego, CA 92123

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