4100 N Main St
Columbia, SC 29203
Office Property For Sale

We are pleased to present this exclusive owner-user medical office opportunity at 4100 North Main Street, a well-located multi-tenant medical office building situated along a primary commercial and healthcare corridor in Columbia, South Carolina. The property offers a compelling combination of immediate usability, durable in-place medical tenancy, and long-term value creation potential, supported by a recent third-party appraisal valuing the asset at approximately $2.83 million in November 2025.

The asset is uniquely positioned for a medical or professional owner-user seeking to acquire and occupy a significant portion of a purpose-built medical office building, while benefiting from existing tenancy that helps offset operating and carrying costs. This structure allows an incoming user to control its real estate, reduce long-term occupancy risk, and avoid the time and cost associated with new development or extensive build-to-suit construction.

In-place tenancy includes AIDS Healthcare Foundation, a nationally recognized healthcare provider, secured under a long-term lease through January 2032, providing stability and credibility to the rent roll. The remaining tenancy consists of medical and wellness-oriented users consistent with the property’s design and location within the corridor.

The offering provides buyers the opportunity to acquire a well-located medical office asset at a basis supported by recent appraised value and below long-term stabilized levels, creating a clear path to build equity through owner occupancy and operational control rather than relying on speculative future assumptions. This value-oriented entry point is particularly attractive for users seeking to invest in their own real estate while maintaining flexibility and downside protection.

The building has benefited from strategic capital improvements completed in 2020–2021, including roof replacement and interior upgrades, aligning the property with modern medical office requirements and minimizing near-term capital expenditure needs. Strong visibility, surface parking, and zoning flexibility further enhance long-term utility and marketability.

Overall, 4100 North Main Street represents a rare owner-user acquisition opportunity in an established medical corridor—offering control, income support, appraised value support, and long-term value creation in a single, efficient real estate solution.