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4220 Duncan Ave 7,783 SF of 5-Star Retail Space Available in Saint Louis, MO 63110
HIGHLIGHTS
- 4220 Duncan Avenue offers a 5,263-square-foot turnkey restaurant with two spacious patios, perfect for high-capacity dining or entertainment concepts.
- Located in the heart of Cortex, surrounded by major tenants such as Microsoft, Boeing, Accenture, and Cambridge Innovation Center (CIC).
- Close to Downtown St. Louis attractions, event venues, and major employers, supporting steady lunch, happy hour, and evening demand.
- Features a modern interior layout ideal for high-volume service, with a spacious dining area, bar setup, and commercial-grade kitchen infrastructure.
- Positioned steps from the Cortex MetroLink Station and minutes from Interstate 64, offering unmatched regional and local connectivity.
- Strong demographic base with 146,000 nearby residents, 41% college-educated, and 141,000 daytime employees fueling consistent foot traffic.
ALL AVAILABLE SPACE(1)
Display Rental Rate as
- SPACE
- SIZE
- TERM
- RENTAL RATE
- SPACE USE
- CONDITION
- AVAILABLE
Seize the opportunity to establish your business in one of St. Louis’ most dynamic and thriving innovation hubs. This fully built-out 5,263-square-foot restaurant space is available immediately and includes two expansive outdoor patios totaling 2,126 square feet, and a 394-square-foot cafe, ideal for high-volume dining, bar, and restaurant. Position your concept at the epicenter of innovation and connectivity in St. Louis, perfect for operators seeking a high-energy, high-growth location.
- Listed rate may not include certain utilities, building services and property expenses
- Space is in Excellent Condition
- Fully Built-Out as a Restaurant or Café Space
| Space | Size | Term | Rental Rate | Space Use | Condition | Available |
| 1st Floor | 7,783 SF | 1-10 Years | $18.00 /SF/YR $1.50 /SF/MO $140,094 /YR $11,675 /MO | Retail | Full Build-Out | Now |
1st Floor
| Size |
| 7,783 SF |
| Term |
| 1-10 Years |
| Rental Rate |
| $18.00 /SF/YR $1.50 /SF/MO $140,094 /YR $11,675 /MO |
| Space Use |
| Retail |
| Condition |
| Full Build-Out |
| Available |
| Now |
1st Floor
| Size | 7,783 SF |
| Term | 1-10 Years |
| Rental Rate | $18.00 /SF/YR |
| Space Use | Retail |
| Condition | Full Build-Out |
| Available | Now |
Seize the opportunity to establish your business in one of St. Louis’ most dynamic and thriving innovation hubs. This fully built-out 5,263-square-foot restaurant space is available immediately and includes two expansive outdoor patios totaling 2,126 square feet, and a 394-square-foot cafe, ideal for high-volume dining, bar, and restaurant. Position your concept at the epicenter of innovation and connectivity in St. Louis, perfect for operators seeking a high-energy, high-growth location.
- Listed rate may not include certain utilities, building services and property expenses
- Fully Built-Out as a Restaurant or Café Space
- Space is in Excellent Condition
SELECT TENANTS
- FLOOR
- TENANT NAME
- INDUSTRY
- 5th
- Accenture
- Professional, Scientific, and Technical Services
- 4th
- AON
- Professional, Scientific, and Technical Services
- 2nd
- Atlas Public Schools
- Services
- Multiple
- Cambridge Innovation Center
- Real Estate
- 5th
- Microsoft Corporation
- Information
- 1st
- Move by BJC
- Arts, Entertainment, and Recreation
- 2nd
- Swipesum
- Finance and Insurance
- Multiple
- The Boeing Company
- Manufacturing
- 1st
- Wirth Leadership & Coaching
- Educational Services
PROPERTY FACTS
PROPERTY OVERVIEW
Nestled in the heart of St. Louis’ thriving Cortex Innovation Community, 4220 Duncan Avenue presents a rare opportunity to lease a fully built-out 5,263-square-foot restaurant space, complete with two expansive outdoor patios totaling 2,126 square feet and a 394-square-foot cafe. This turnkey space is primed for immediate occupancy and tailored for high-volume food and beverage operations. Designed with exceptional interior finishes and excellent condition throughout, this space offers operators a ready-made platform to serve one of the Midwest's most vibrant business and tech ecosystems. With on-site anchor tenants such as Microsoft, Boeing, Accenture, and the Cambridge Innovation Center, 4220 Duncan Avenue delivers a steady flow of professionals and innovators looking for premium dining experiences. Positioned off Interstate 64 and mere steps from the Cortex MetroLink Station, 4220 Duncan Avenue offers excellent connectivity to key destinations, including Downtown St. Louis, the airport, and surrounding districts. This highly walkable and well-connected location places it at the nexus of business, transit, and culture. Within a 3-mile radius, the area is home to 146,000 residents, 41% of whom hold a bachelor’s degree or higher, creating a strong, educated local demographic with purchasing power. Furthermore, over 141,000 daytime employees commute into the area daily, contributing to a steady demand for dining and catering opportunities. Within minutes, visitors can reach Downtown St. Louis, where entertainment, culture, and tourism converge at the Gateway Arch, Busch Stadium, and various event venues. As one of the region’s most transformative and fastest-growing districts, the Cortex Innovation Community delivers a distinct blend of technology, education, and urban energy. Surrounded by world-class institutions, healthcare facilities, and research centers, the neighborhood fosters a unique culture of creativity and collaboration. The strategic advantages of the building, the strength of the location, and the density of nearby talent and traffic make 4220 Duncan Avenue a high-impact choice for restaurant operators ready to grow within a forward-looking, opportunity-rich market.
- 24 Hour Access
- Bus Line
- Controlled Access
- Commuter Rail
- Concierge
- Conferencing Facility
- Fitness Center
- Property Manager on Site
- Security System
- Signage
- Kitchen
- Atrium
- Bicycle Storage
- High Ceilings
- Natural Light
- Plug & Play
- Shower Facilities
- Wi-Fi
- Air Conditioning
NEARBY MAJOR RETAILERS
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4220 Duncan Ave
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