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4300 Duncan Ave 4,144 - 40,266 SF of 5-Star Office Space Available in Saint Louis, MO 63110

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HIGHLIGHTS

  • Building conference and collaboration spaces
  • Plentiful visitor parking
  • Adjacent garage and surface parking

ALL AVAILABLE SPACES(2)

Display Rental Rate as

  • SPACE
  • SIZE
  • TERM
  • RENTAL RATE
  • SPACE USE
  • CONDITION
  • AVAILABLE
  • 2nd Floor, Ste 204
  • 4,144 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now
  • Fits 11 - 34 People
  • 4th Floor, Ste 400
  • 36,122 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • May 01, 2026

- Top floor vacancy - Full floor opportunity - Excellent existing conditions - 31 private offices and an IT room - Building signage opportunity - Available 5/1/2026

  • Fits 91 - 289 People
Space Size Term Rental Rate Space Use Condition Available
2nd Floor, Ste 204 4,144 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
4th Floor, Ste 400 36,122 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - May 01, 2026

2nd Floor, Ste 204

Size
4,144 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
Now

4th Floor, Ste 400

Size
36,122 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
May 01, 2026

2nd Floor, Ste 204

Size 4,144 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition -
Available Now

  • Fits 11 - 34 People

4th Floor, Ste 400

Size 36,122 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition -
Available May 01, 2026

- Top floor vacancy - Full floor opportunity - Excellent existing conditions - 31 private offices and an IT room - Building signage opportunity - Available 5/1/2026

  • Fits 91 - 289 People

PROPERTY OVERVIEW

Architecturally striking and built to Fortune 500 standards, 4300 Duncan is a future-forward workplace with technology and collaboration at its core. Infused with equal parts productivity and lifestyle, 4300 Duncan is situated at the center of the Cortex Innovation District; a gravitational hub for top global talent. Cortex is a vibrant, 200-acre hub of business, innovation, and technology integrated into St. Louis’ historic Central West End and Forest Park Southeast neighborhoods, surrounded by nationally-ranked universities and medical centers and abundant cultural and recreational assets. Cortex is a catalyst for innovation that brings together big-thinking problem solvers with state-of-the-art resources, facilities, and innovative programming to inspire and drive collaboration.

  • Bio-Tech/ Lab Space
  • Courtyard
  • Metro/Subway
  • Security System
  • Signage

PROPERTY FACTS

Building Type
Office
Year Built
2008
LoopNet Rating
5 Star
Building Height
4 Stories
Building Size
189,841 SF
Building Class
A
Typical Floor Size
43,000 SF
Unfinished Ceiling Height
14’
Parking
218 Surface Parking Spaces
222 Covered Parking Spaces

ATTACHMENTS

4300 Duncan Ave
Walk Score®
Very Walkable (73)
What is a Walk Score®, Transit Score® & Bike Score®?
Walk Score® measures the walkability of any address.
Transit Score® measures access to public transit.
Bike Score® measures bikeability of a location.
What is a Walk Score®
, Transit Score® & Bike Score?
Walk Score® measures the walkability
of any address. Transit Score®
measures access to public transit. Bike Score®
measures bikeability of a location.®
  • Listing ID: 24663167

  • Date on Market: 8/19/2025

  • Last Updated:

  • Address: 4300 Duncan Ave, Saint Louis, MO 63110

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