Office/Medical Office or Redevelopment 4603 Salisbury rd 46,468 SF 100% Leased Office Building Jacksonville, FL 32256 $5,500,000 ($118.36/SF)

Value-Add Office/Medical Investment & Multifamily Redevelopment Opportunity
Positioned in the heart of Jacksonville's thriving Southpoint submarket, 4063 Salisbury Road presents a rare opportunity to acquire a ±46,468-square-foot office and medical office campus with significant repositioning and long-term redevelopment potential. Situated on approximately 2.5 acres within one of Northeast Florida's most established business corridors, the property offers investors and owner-users a highly accessible location surrounded by major healthcare providers, employment centers, and rapidly growing residential communities.
Currently improved with a two-story, multi-tenant office and medical building totaling approximately ±41,102 square feet, the property is ideally suited for an owner-user seeking to occupy a portion of the building while generating income from existing tenants or for an investor pursuing a strategic value-add leasing and repositioning program. Originally constructed in 1990, the building features flexible floor plates, a covered entry, ample natural light, approximately 190 surface parking spaces, and a parking ratio of 4.5 spaces per 1,000 square feet. Recent capital improvements include a roof replacement completed in 2017.
Located within the Southpoint Business Park, one of Jacksonville's premier office and healthcare submarkets, the property benefits from exceptional connectivity to the region's major transportation corridors. The site is less than one mile from Interstate 95, approximately 1.3 miles from J. Turner Butler Boulevard (SR-202), and offers convenient access to Interstate 295 and U.S. Highway 1. Downtown Jacksonville is approximately 10 minutes away, while Jacksonville Beaches, St. Johns Town Center, and Jacksonville International Airport are all within a short drive.
The immediate area is anchored by a robust healthcare ecosystem that continues to drive demand for medical office space. The property is strategically positioned near major healthcare providers including:
Baptist Medical Center Jacksonville
Ascension St. Vincent's Southside Hospital
HCA Florida Memorial Hospital
Mayo Clinic Jacksonville
This concentration of hospitals, specialty practices, outpatient facilities, and healthcare support services creates a strong foundation for continued medical office demand and supports a wide range of potential uses, including physician groups, outpatient clinics, behavioral health, imaging centers, physical therapy, wellness providers, and professional services.
Beyond its existing office and medical functionality, 4063 Salisbury Road offers compelling long-term redevelopment potential. The Southpoint and Southside corridors continue to experience substantial population growth, employment expansion, and increasing demand for multifamily housing. Jacksonville's pro-growth environment, combined with the property's central infill location and proximity to major employment nodes, positions the site as a potential candidate for future multifamily or mixed-use redevelopment, subject to zoning verification and municipal approvals.
The surrounding area boasts strong demographic fundamentals, with more than 205,000 residents within a five-mile radius, projected population growth exceeding 6% over the next five years, and median household incomes approaching $69,000. The area's established workforce, expanding healthcare sector, and ongoing residential development continue to fuel demand for well-located commercial and multifamily assets.
Investment Highlights:
±46,468 SF campus with ±41,102 SF existing office/medical improvements
Approximately 2.5-acre site within Jacksonville's premier Southpoint submarket
Flexible owner-user, value-add investment, or redevelopment opportunity
Existing medical office infrastructure with established healthcare tenancy
Strong parking ratio with approximately 190 surface spaces
Immediate access to I-95, SR-202 (JTB), I-295, and U.S. 1
Minutes from Downtown Jacksonville, St. Johns Town Center, and Jacksonville Beaches
Surrounded by major hospitals, medical providers, and corporate employers
Potential multifamily or mixed-use redevelopment opportunity subject to approvals
Located within one of Northeast Florida's fastest-growing employment and residential corridors
4063 Salisbury Road represents a unique opportunity to acquire a strategically located asset with multiple paths to value creation—whether through owner occupancy, medical office repositioning, lease-up, or future redevelopment in one of Jacksonville's most dynamic and resilient submarkets.