5751 Blythewood St
Houston, TX 77021
Building 2 · Office Property For Sale

5751 Blythewood Street, Suites 700 and 800, offers the opportunity to acquire a 5,121 SF professional office property positioned within Houston’s established South Main and Texas Medical Center area. The property benefits from signage exposure along Old Spanish Trail and convenient access to Loop 610, Interstate 45, and State Highway 288, providing connectivity to major employment centers throughout the Houston market. The location's proximity to the Texas Medical Center supports a wide range of professional, medical, and office-oriented users seeking access to one of the region’s largest healthcare and employment hubs.
The property consists of two contiguous office suites that have historically supported medical and professional office operations. Suite 700 was previously occupied by a medical user, while Suite 800 has served as both a medical office and bank branch. Recent interior improvements in Suite 800 include updated finishes throughout the space. Existing layouts feature professional office buildouts with reception, office, workroom, breakroom, and support areas that can accommodate a variety of owner-user or investor strategies.
With abundant on-site parking, established office infrastructure, and strong regional accessibility, the property presents a compelling opportunity for businesses seeking a well-located headquarters, medical practice, professional services office, or investment asset in a highly connected Houston submarket.