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Sublease Highlights

  • Located within The Engine innovation campus developed in partnership with MIT.
  • Redeveloped building supporting office and life science users.
  • On-site parking, bicycle storage, and outdoor gathering areas.
  • Positioned between Kendall Square and Central Square.
  • Access to shared conference, collaboration, and event facilities.
  • Surrounded by Cambridge's research, technology, and academic ecosystem.

All Available Space(1)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • 4th Floor
  • 3,000-10,000 SF
  • Dec 2028
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now

Incredible opportunity to sublease or share furnished office and fully equipped Lab space in the Heart of Cambridge. Office: Open Space with desks, 3 huddle rooms (large enough to serve as a 4-5 person conference room) Lab: Half of the bench space, 1 fume hood, and a large TC room with 3 dedicated BSCs.

  • Sublease space available from current tenant
  • Fully Built-Out as Standard Office
  • Fits 8 - 50 People
  • 1 Workstation
  • Laboratory
  • Exposed Ceiling
  • Shower Facilities
  • Lab Equipment
  • Lease rate does not include utilities, property expenses or building services
  • Mostly Open Floor Plan Layout
  • 3 Private Offices
  • Plug & Play
  • Elevator Access
  • Bicycle Storage
  • Fume Hoods
  • Glasswash
Space Size Term Rental Rate Space Use Build-Out Available
4th Floor 3,000-10,000 SF Dec 2028 Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now

4th Floor

Size
3,000-10,000 SF
Term
Dec 2028
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
Full Build-Out
Available
Now

4th Floor

Size 3,000-10,000 SF
Term Dec 2028
Rental Rate Upon Request
Space Use Office
Build-Out Full Build-Out
Available Now

Incredible opportunity to sublease or share furnished office and fully equipped Lab space in the Heart of Cambridge. Office: Open Space with desks, 3 huddle rooms (large enough to serve as a 4-5 person conference room) Lab: Half of the bench space, 1 fume hood, and a large TC room with 3 dedicated BSCs.

  • Sublease space available from current tenant
  • Lease rate does not include utilities, property expenses or building services
  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Fits 8 - 50 People
  • 3 Private Offices
  • 1 Workstation
  • Plug & Play
  • Laboratory
  • Elevator Access
  • Exposed Ceiling
  • Bicycle Storage
  • Shower Facilities
  • Fume Hoods
  • Lab Equipment
  • Glasswash

Property Overview

730 Main Street is a five-story office and life science building located in Cambridge's innovation district. The property is part of The Engine campus at 730-750 Main Street, a redeveloped research and technology complex associated with MIT. Originally constructed as an industrial facility and comprehensively redeveloped in 2022, the building supports office, laboratory, research, fabrication, and collaborative work environments. The property is located along Main Street between Kendall Square and Central Square, providing access to public transportation, academic institutions, research organizations, restaurants, hotels, and neighborhood retail services. On-site features include structured parking, bicycle storage, conference facilities, outdoor gathering areas, and shared campus amenities.

Property Facts

Building Type
Office
Year Built/Renovated
2021/2022
Building Height
5 Stories
Building Size
57,000 SF
Building Class
B
Typical Floor Size
11,400 SF

Select Tenants

  • Floor
  • Tenant Name
  • Industry
  • 1st
  • BRED
  • Accommodation and Food Services
  • 1st
  • Dem Biopharma Inc
  • Public Administration
Exceptionally walkable
100/100
Moderately drivable
60/100
Exceptional public transit
90/100
Exceptionally bikeable
90/100
  • Listing ID: 41704833

  • Date on Market: 8/11/2026

  • Last Updated:

  • Address: 730 Main St, Cambridge, MA 02139

Contact the Leasing Agent

730 Main St

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