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730 Main St 3,000 - 10,000 SF of Office Space Available in Cambridge, MA 02139



Sublease Highlights
- Located within The Engine innovation campus developed in partnership with MIT.
- Redeveloped building supporting office and life science users.
- On-site parking, bicycle storage, and outdoor gathering areas.
- Positioned between Kendall Square and Central Square.
- Access to shared conference, collaboration, and event facilities.
- Surrounded by Cambridge's research, technology, and academic ecosystem.
All Available Space(1)
Display Rental Rate as
- Space
- Size
- Term
- Rental Rate
- Space Use
- Build-Out
- Available
Incredible opportunity to sublease or share furnished office and fully equipped Lab space in the Heart of Cambridge. Office: Open Space with desks, 3 huddle rooms (large enough to serve as a 4-5 person conference room) Lab: Half of the bench space, 1 fume hood, and a large TC room with 3 dedicated BSCs.
- Sublease space available from current tenant
- Fully Built-Out as Standard Office
- Fits 8 - 50 People
- 1 Workstation
- Laboratory
- Exposed Ceiling
- Shower Facilities
- Lab Equipment
- Lease rate does not include utilities, property expenses or building services
- Mostly Open Floor Plan Layout
- 3 Private Offices
- Plug & Play
- Elevator Access
- Bicycle Storage
- Fume Hoods
- Glasswash
| Space | Size | Term | Rental Rate | Space Use | Build-Out | Available |
| 4th Floor | 3,000-10,000 SF | Dec 2028 | Upon Request Upon Request Upon Request Upon Request | Office | Full Build-Out | Now |
4th Floor
| Size |
| 3,000-10,000 SF |
| Term |
| Dec 2028 |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office |
| Build-Out |
| Full Build-Out |
| Available |
| Now |
4th Floor
| Size | 3,000-10,000 SF |
| Term | Dec 2028 |
| Rental Rate | Upon Request |
| Space Use | Office |
| Build-Out | Full Build-Out |
| Available | Now |
Incredible opportunity to sublease or share furnished office and fully equipped Lab space in the Heart of Cambridge. Office: Open Space with desks, 3 huddle rooms (large enough to serve as a 4-5 person conference room) Lab: Half of the bench space, 1 fume hood, and a large TC room with 3 dedicated BSCs.
- Sublease space available from current tenant
- Lease rate does not include utilities, property expenses or building services
- Fully Built-Out as Standard Office
- Mostly Open Floor Plan Layout
- Fits 8 - 50 People
- 3 Private Offices
- 1 Workstation
- Plug & Play
- Laboratory
- Elevator Access
- Exposed Ceiling
- Bicycle Storage
- Shower Facilities
- Fume Hoods
- Lab Equipment
- Glasswash
Property Overview
730 Main Street is a five-story office and life science building located in Cambridge's innovation district. The property is part of The Engine campus at 730-750 Main Street, a redeveloped research and technology complex associated with MIT. Originally constructed as an industrial facility and comprehensively redeveloped in 2022, the building supports office, laboratory, research, fabrication, and collaborative work environments. The property is located along Main Street between Kendall Square and Central Square, providing access to public transportation, academic institutions, research organizations, restaurants, hotels, and neighborhood retail services. On-site features include structured parking, bicycle storage, conference facilities, outdoor gathering areas, and shared campus amenities.
Property Facts
Select Tenants
- Floor
- Tenant Name
- Industry
- 1st
- BRED
- Accommodation and Food Services
- 1st
- Dem Biopharma Inc
- Public Administration
Contact the Leasing Agent
730 Main St

