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Napa Innovation Center 1250 Main St 200 - 28,035 SF of Space Available in Napa, CA 94559

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HIGHLIGHTS

  • Class A Building in Napa, Wine & Culinary Capital of the World
  • Global Wine Production Hub, Leveraging Regional Prestige
  • Access to Skilled Workforce in Hospitality, Wine, Food, and Tech
  • Ideal Location for AgTech, MedTech, CleanTech & Professional Service Businesses
  • High Visibility & Thriving Local Economy for Strategic Growth
  • 2,500 to 14,000 sq ft of office and medical space in Napa Innovation Center

Display Rental Rate as

  • SPACE
  • SIZE
  • TERM
  • RENTAL RATE
  • SPACE USE
  • CONDITION
  • AVAILABLE
  • 2nd Floor, Ste 200
  • 200 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now
  • Rate includes utilities, building services and property expenses
  • Fits 1 - 2 People
  • 3rd Floor, Ste 300
  • 13,085 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now
  • Fits 20 - 30 People
  • 3rd Floor, Ste 300A
  • 7,113 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now
  • Fits 5 - 10 People
  • 3rd Floor, Ste 325A
  • 3,223 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now
  • Fits 8 - 10 People
  • 3rd Floor, Ste 350A
  • 3,476 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now
  • Fits 9 - 28 People
Space Size Term Rental Rate Space Use Condition Available
2nd Floor, Ste 200 200 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
3rd Floor, Ste 300 13,085 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
3rd Floor, Ste 300A 7,113 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
3rd Floor, Ste 325A 3,223 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
3rd Floor, Ste 350A 3,476 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now

2nd Floor, Ste 200

Size
200 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
Now

3rd Floor, Ste 300

Size
13,085 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
Now

3rd Floor, Ste 300A

Size
7,113 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
Now

3rd Floor, Ste 325A

Size
3,223 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
Now

3rd Floor, Ste 350A

Size
3,476 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
Now
Spaces are matched based on search filters: space use, price, and size
  • SPACE
  • SIZE
  • TERM
  • RENTAL RATE
  • SPACE USE
  • CONDITION
  • AVAILABLE
  • 1st Floor, Ste 1245 West Street
  • 938 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Retail
  • Full Build-Out
  • January 01, 2026

Napa Innovation Center, located at 1250 Main Street in downtown Napa, CA is a Class A office building offering approximately 50,000 square feet of professional space designed for modern business needs. With its striking architecture and prominent corner presence at Main and Clinton Streets, this three-story building delivers both visibility and prestige in one of Napa’s most walkable and dynamic commercial districts. Surrounded by top-tier restaurants, boutique retail, luxury hotels, and cultural destinations, the property boasts a Walk Score of 97—placing tenants at the center of it all. The building features a variety of fully built-out suites ranging from private offices to expansive, full-floor layouts, allowing businesses to scale and customize as needed. Inside, tenants are welcomed by elegant stone lobby flooring, high-end finishes, and abundant natural light through double-pane, tinted glass windows. Each floor is served by elevator access and includes well-appointed restrooms, creating a professional and comfortable environment for staff and guests alike. With modern energy management systems, high-speed data connectivity, and keyless after-hours access, Napa Innovation Center is built to meet the demands of today’s high-performance teams. Parking is available with 30 surface spaces offered at an affordable monthly rate—an invaluable asset in Napa’s bustling downtown. Beyond its physical features, the property offers a strategic advantage as part of Napa’s thriving business ecosystem. Known globally for its wine industry, culture, and culinary excellence, the region also supports a growing network of companies in technology, healthcare, design, and professional services. Its central location provides convenient access to major transportation routes and is within one hour of three international airports, offering seamless local and international connectivity. For companies seeking a prestigious address that balances form and function in one of Northern California’s most iconic destinations, Napa Innovation Center at 1250 Main Street delivers a rare and compelling opportunity to thrive in the heart of downtown Napa.

  • Lease rate does not include utilities, property expenses or building services
  • High End Trophy Space
  • Partitioned Offices
  • Print/Copy Room
  • Corner Space
  • Secure Storage
  • Plug & Play
  • Finished Ceilings: 9’11”
  • Hardwood Floors
  • Wheelchair Accessible
  • Fully Built-Out as Professional Services Office
  • Central Air Conditioning
  • Private Restrooms
  • Fully Carpeted
  • Drop Ceilings
  • Recessed Lighting
  • After Hours HVAC Available
  • Demised WC facilities
  • Smoke Detector
  • 2nd Floor, Ste 200
  • 200 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now
  • Rate includes utilities, building services and property expenses
  • Fits 1 - 2 People
  • 3rd Floor, Ste 300
  • 13,085 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now
  • Fits 20 - 30 People
  • 3rd Floor, Ste 300A
  • 7,113 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now
  • Fits 5 - 10 People
  • 3rd Floor, Ste 325A
  • 3,223 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now
  • Fits 8 - 10 People
  • 3rd Floor, Ste 350A
  • 3,476 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now
  • Fits 9 - 28 People
Space Size Term Rental Rate Space Use Condition Available
1st Floor, Ste 1245 West Street 938 SF Negotiable Upon Request Upon Request Upon Request Upon Request Retail Full Build-Out January 01, 2026
2nd Floor, Ste 200 200 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
3rd Floor, Ste 300 13,085 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
3rd Floor, Ste 300A 7,113 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
3rd Floor, Ste 325A 3,223 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
3rd Floor, Ste 350A 3,476 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now

1st Floor, Ste 1245 West Street

Size
938 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Retail
Condition
Full Build-Out
Available
January 01, 2026

2nd Floor, Ste 200

Size
200 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
Now

3rd Floor, Ste 300

Size
13,085 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
Now

3rd Floor, Ste 300A

Size
7,113 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
Now

3rd Floor, Ste 325A

Size
3,223 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
Now

3rd Floor, Ste 350A

Size
3,476 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
-
Available
Now

1st Floor, Ste 1245 West Street

Size 938 SF
Term Negotiable
Rental Rate Upon Request
Space Use Retail
Condition Full Build-Out
Available January 01, 2026

Napa Innovation Center, located at 1250 Main Street in downtown Napa, CA is a Class A office building offering approximately 50,000 square feet of professional space designed for modern business needs. With its striking architecture and prominent corner presence at Main and Clinton Streets, this three-story building delivers both visibility and prestige in one of Napa’s most walkable and dynamic commercial districts. Surrounded by top-tier restaurants, boutique retail, luxury hotels, and cultural destinations, the property boasts a Walk Score of 97—placing tenants at the center of it all. The building features a variety of fully built-out suites ranging from private offices to expansive, full-floor layouts, allowing businesses to scale and customize as needed. Inside, tenants are welcomed by elegant stone lobby flooring, high-end finishes, and abundant natural light through double-pane, tinted glass windows. Each floor is served by elevator access and includes well-appointed restrooms, creating a professional and comfortable environment for staff and guests alike. With modern energy management systems, high-speed data connectivity, and keyless after-hours access, Napa Innovation Center is built to meet the demands of today’s high-performance teams. Parking is available with 30 surface spaces offered at an affordable monthly rate—an invaluable asset in Napa’s bustling downtown. Beyond its physical features, the property offers a strategic advantage as part of Napa’s thriving business ecosystem. Known globally for its wine industry, culture, and culinary excellence, the region also supports a growing network of companies in technology, healthcare, design, and professional services. Its central location provides convenient access to major transportation routes and is within one hour of three international airports, offering seamless local and international connectivity. For companies seeking a prestigious address that balances form and function in one of Northern California’s most iconic destinations, Napa Innovation Center at 1250 Main Street delivers a rare and compelling opportunity to thrive in the heart of downtown Napa.

  • Lease rate does not include utilities, property expenses or building services
  • Fully Built-Out as Professional Services Office
  • High End Trophy Space
  • Central Air Conditioning
  • Partitioned Offices
  • Private Restrooms
  • Print/Copy Room
  • Fully Carpeted
  • Corner Space
  • Drop Ceilings
  • Secure Storage
  • Recessed Lighting
  • Plug & Play
  • After Hours HVAC Available
  • Finished Ceilings: 9’11”
  • Demised WC facilities
  • Hardwood Floors
  • Smoke Detector
  • Wheelchair Accessible

2nd Floor, Ste 200

Size 200 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition -
Available Now

  • Rate includes utilities, building services and property expenses
  • Fits 1 - 2 People

3rd Floor, Ste 300

Size 13,085 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition -
Available Now

  • Fits 20 - 30 People

3rd Floor, Ste 300A

Size 7,113 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition -
Available Now

  • Fits 5 - 10 People

3rd Floor, Ste 325A

Size 3,223 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition -
Available Now

  • Fits 8 - 10 People

3rd Floor, Ste 350A

Size 3,476 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Condition -
Available Now

  • Fits 9 - 28 People

MATTERPORT 3D TOUR

Napa Innovation Center 3rd Floor

PROPERTY OVERVIEW

Napa Innovation Center, located at 1250 Main Street in downtown Napa, CA is a Class A office building offering approximately 50,000 square feet of professional space designed for modern business needs. With its striking architecture and prominent corner presence at Main and Clinton Streets, this three-story building delivers both visibility and prestige in one of Napa’s most walkable and dynamic commercial districts. Surrounded by top-tier restaurants, boutique retail, luxury hotels, and cultural destinations, the property boasts a Walk Score of 97—placing tenants at the center of it all. The building features a variety of fully built-out suites ranging from private offices to expansive, full-floor layouts, allowing businesses to scale and customize as needed. Inside, tenants are welcomed by elegant stone lobby flooring, high-end finishes, and abundant natural light through double-pane, tinted glass windows. Each floor is served by elevator access and includes well-appointed restrooms, creating a professional and comfortable environment for staff and guests alike. With modern energy management systems, high-speed data connectivity, and keyless after-hours access, Napa Innovation Center is built to meet the demands of today’s high-performance teams. Parking is available with 30 surface spaces offered at an affordable monthly rate—an invaluable asset in Napa’s bustling downtown. Beyond its physical features, the property offers a strategic advantage as part of Napa’s thriving business ecosystem. Known globally for its wine industry, culture, and culinary excellence, the region also supports a growing network of companies in technology, healthcare, design, and professional services. Its central location provides convenient access to major transportation routes and is within one hour of three international airports, offering seamless local and international connectivity. For companies seeking a prestigious address that balances form and function in one of Northern California’s most iconic destinations, Napa Innovation Center at 1250 Main Street delivers a rare and compelling opportunity to thrive in the heart of downtown Napa.

  • 24 Hour Access
  • Controlled Access
  • Restaurant
  • Air Conditioning

PROPERTY FACTS

Building Type
Office
Year Built/Renovated
2008/2025
Building Height
3 Stories
Building Size
45,455 SF
Building Class
A
Typical Floor Size
13,000 SF
Unfinished Ceiling Height
13’
Parking
30 Surface Parking Spaces at $30/month
Covered Parking
Walk Score®
Walker's Paradise (96)
Bike Score®
Very Bikeable (83)
What is a Walk Score®, Transit Score® & Bike Score®?
Walk Score® measures the walkability of any address.
Transit Score® measures access to public transit.
Bike Score® measures bikeability of a location.
What is a Walk Score®
, Transit Score® & Bike Score?
Walk Score® measures the walkability
of any address. Transit Score®
measures access to public transit. Bike Score®
measures bikeability of a location.®
  • Listing ID: 22142517

  • Date on Market: 11/18/2025

  • Last Updated:

  • Address: 1250 Main St, Napa, CA 94559

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