22 S Main 22 S Main St 8,500 SF of Retail Space Available in Greenville, SC 29601

Position your business in the heart of Downtown Greenville with this exceptional retail opportunity at 22 S. Main Street. Offering approximately 8,500 SF of prime ground-floor space, this property is ideally situated along Greenville’s most vibrant retail corridor, directly across from the Wells Fargo Tower. A new façade renovation is underway, ensuring a modern and inviting storefront that will enhance visibility and curb appeal for future tenants. The property benefits from heavy pedestrian and vehicular traffic, with Main Street seeing over 7,200 vehicles per day and McBee Avenue over 7,000 VPD. Surrounded by a dynamic mix of national and local retailers, popular restaurants, and entertainment venues, this location offers unmatched exposure and synergy. Nearby establishments include Methodical Coffee, Anthropologie, Tupelo Honey, Cantina 76, and Mast General Store, creating a strong co-tenancy environment. Downtown Greenville is a thriving destination for residents, visitors, and businesses, with a growing population and robust household incomes averaging over $140,000 within a one-mile radius. The area attracts significant visitor spending, with $793 million allocated to attractions, retail, and entertainment annually. This property is perfectly positioned to capture that demand, making it an ideal choice for flagship retail, experiential concepts, or destination dining.