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All Available Space(1)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • 2nd Floor
  • 1,691 SF
  • Sep 2030
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now

Located in the heart of East Cambridge’s Kendall Square submarket, the American Twine Building is a historic brick and beam office building just a short walk from the Kendall Square Red Line and Lechmere Green Line MBTA stations, surrounded by new restaurant and retail offerings. Originally an industrial property, the approximately 122,000 SF building sits on a nearly two-acre site, placing tenants steps from world-class universities and a thriving ecosystem of biotech and technology companies, with close proximity to both MIT and Harvard providing access to a deep pool of elite talent. This ±1,691 SF suite offers the building’s signature character, exposed brick and beams with large windows that allow an abundance of natural light throughout. The space is ideally suited for a growing technology, professional services, or life science administrative user seeking a creative office environment with built-in flexibility and a defined term.

  • Sublease space available from current tenant
  • Fully Built-Out as Standard Office
  • Space is in Excellent Condition
  • Historic brick and beam construction
  • Steps from CambridgeSide and East Cambridge’s
  • Walkable to Lechmere (Green Line
  • Listed rate may not include certain utilities, building services and property expenses
  • Mostly Open Floor Plan Layout
  • Secure Storage
  • on-site reserved parking, 24-hour security
  • Walkable to Kendall/MIT (Red Line)
Space Size Term Rental Rate Space Use Build-Out Available
2nd Floor 1,691 SF Sep 2030 Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now

2nd Floor

Size
1,691 SF
Term
Sep 2030
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
Full Build-Out
Available
Now

2nd Floor

Size 1,691 SF
Term Sep 2030
Rental Rate Upon Request
Space Use Office
Build-Out Full Build-Out
Available Now

Located in the heart of East Cambridge’s Kendall Square submarket, the American Twine Building is a historic brick and beam office building just a short walk from the Kendall Square Red Line and Lechmere Green Line MBTA stations, surrounded by new restaurant and retail offerings. Originally an industrial property, the approximately 122,000 SF building sits on a nearly two-acre site, placing tenants steps from world-class universities and a thriving ecosystem of biotech and technology companies, with close proximity to both MIT and Harvard providing access to a deep pool of elite talent. This ±1,691 SF suite offers the building’s signature character, exposed brick and beams with large windows that allow an abundance of natural light throughout. The space is ideally suited for a growing technology, professional services, or life science administrative user seeking a creative office environment with built-in flexibility and a defined term.

  • Sublease space available from current tenant
  • Listed rate may not include certain utilities, building services and property expenses
  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Space is in Excellent Condition
  • Secure Storage
  • Historic brick and beam construction
  • on-site reserved parking, 24-hour security
  • Steps from CambridgeSide and East Cambridge’s
  • Walkable to Kendall/MIT (Red Line)
  • Walkable to Lechmere (Green Line

Property Overview

Located in the heart of East Cambridge’s Kendall Square submarket, the American Twine Building is a historic brick and beam office building just a short walk from the Kendall Square Red Line and Lechmere Green Line MBTA stations, surrounded by new restaurant and retail offerings. Originally an industrial property, the approximately 122,000 SF building sits on a nearly two-acre site, placing tenants steps from world-class universities and a thriving ecosystem of biotech and technology companies, with close proximity to both MIT and Harvard providing access to a deep pool of elite talent. This ±1,691 SF suite offers the building’s signature character, exposed brick and beams with large windows that allow an abundance of natural light throughout. The space is ideally suited for a growing technology, professional services, or life science administrative user seeking a creative office environment with built-in flexibility and a defined term. •Historic brick and beam construction with abundant natural light • Building amenities include on-site reserved parking, 24-hour security, a grab-and-go café, showers, and a shared conference room • Steps from CambridgeSide and East Cambridge’s restaurant and retail corridor • Walkable to both Kendall/MIT (Red Line) and Lechmere (Green Line) stations; approximately one mile from I-93

  • Atrium
  • Conferencing Facility
  • Fitness Center
  • Property Manager on Site
  • Security System
  • Reception
  • High Ceilings
  • Open-Plan
  • Shower Facilities

Property Facts

Building Type
Office
Year Built/Renovated
1918/1983
Building Height
4 Stories
Building Size
120,668 SF
Building Class
B
Typical Floor Size
22,942 SF
Unfinished Ceiling Height
12’
Parking
90 Surface Parking Spaces

Select Tenants

  • Floor
  • Tenant Name
  • Industry
  • 1st
  • Accenture
  • Professional, Scientific, and Technical Services
  • 1st
  • Automata
  • Professional, Scientific, and Technical Services
  • 2nd
  • Coulter Partners
  • Administrative and Support Services
  • 3rd
  • Eversource Energy Services Company
  • Utilities
  • 3rd
  • Proclara Biosciences, Inc
  • Wholesaler
  • 2nd
  • Rental Beast
  • Real Estate
  • 1st
  • Reversing Labs
  • Professional, Scientific, and Technical Services
  • 1st
  • Schrodinger Inc
  • Information
  • 2nd
  • STEMCELL Technologies
  • Manufacturing
  • 1st
  • Sundial
  • Health Care and Social Assistance
Exceptionally walkable
100/100
Fairly drivable
50/100
Exceptional public transit
90/100
Exceptionally bikeable
100/100
  • Listing ID: 40885762

  • Date on Market: 6/11/2026

  • Last Updated:

  • Address: 222 Third St, Cambridge, MA 02142

Contact the Leasing Agent

222 Third St

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