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333 Oyster Point Blvd 30,440 - 91,320 SF of 4-Star Office Space Available in South San Francisco, CA 94080

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SUBLEASE HIGHLIGHTS

  • ±91,320 SF Divisible Sublease with ±30,440 SF Floor Plates.
  • Fully Built-Out Biology & Tissue Culture Labs.
  • Dedicated Lab Support & Service Areas | House Systems Include CDA & Vacuum.
  • Class A Lab Facility with Advanced Infrastructure.
  • Functional Office Space with Private Offices & Conference Rooms.
  • Shipping & Receiving Area for Operational Efficiency | Emergency Generator On-Site.

ALL AVAILABLE SPACES(3)

Display Rental Rate as

  • SPACE
  • SIZE
  • TERM
  • RENTAL RATE
  • SPACE USE
  • CONDITION
  • AVAILABLE
  • 1st Floor, Ste Office & Lab
  • 30,440 SF
  • Dec 2033
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now

Class A Lab Facility with Advanced Infrastructure.

  • Sublease space available from current tenant
  • Can be combined with additional space(s) for up to 91,320 SF of adjacent space
  • Space is in Excellent Condition
  • 3rd Floor, Ste Lab
  • 30,440 SF
  • Dec 2033
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now

Fully Built-Out Biology & Tissue Culture Labs.

  • Sublease space available from current tenant
  • Can be combined with additional space(s) for up to 91,320 SF of adjacent space
  • Space is in Excellent Condition
  • 4th Floor, Ste Office
  • 30,440 SF
  • Dec 2033
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now

±91,320 SF Divisible Sublease with ±30,440 SF Floor Plates. Functional Office Space with Private Offices & Conference Rooms.

  • Sublease space available from current tenant
  • Mostly Open Floor Plan Layout
  • 59 Private Offices
  • 109 Workstations
  • Can be combined with additional space(s) for up to 91,320 SF of adjacent space
  • Fully Built-Out as Standard Office
  • Fits 77 - 244 People
  • 5 Conference Rooms
  • Space is in Excellent Condition
Space Size Term Rental Rate Space Use Condition Available
1st Floor, Ste Office & Lab 30,440 SF Dec 2033 Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now
3rd Floor, Ste Lab 30,440 SF Dec 2033 Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now
4th Floor, Ste Office 30,440 SF Dec 2033 Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now

1st Floor, Ste Office & Lab

Size
30,440 SF
Term
Dec 2033
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
Full Build-Out
Available
Now

3rd Floor, Ste Lab

Size
30,440 SF
Term
Dec 2033
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
Full Build-Out
Available
Now

4th Floor, Ste Office

Size
30,440 SF
Term
Dec 2033
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Condition
Full Build-Out
Available
Now

1st Floor, Ste Office & Lab

Size 30,440 SF
Term Dec 2033
Rental Rate Upon Request
Space Use Office
Condition Full Build-Out
Available Now

Class A Lab Facility with Advanced Infrastructure.

  • Sublease space available from current tenant
  • Space is in Excellent Condition
  • Can be combined with additional space(s) for up to 91,320 SF of adjacent space

3rd Floor, Ste Lab

Size 30,440 SF
Term Dec 2033
Rental Rate Upon Request
Space Use Office
Condition Full Build-Out
Available Now

Fully Built-Out Biology & Tissue Culture Labs.

  • Sublease space available from current tenant
  • Space is in Excellent Condition
  • Can be combined with additional space(s) for up to 91,320 SF of adjacent space

4th Floor, Ste Office

Size 30,440 SF
Term Dec 2033
Rental Rate Upon Request
Space Use Office
Condition Full Build-Out
Available Now

±91,320 SF Divisible Sublease with ±30,440 SF Floor Plates. Functional Office Space with Private Offices & Conference Rooms.

  • Sublease space available from current tenant
  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Fits 77 - 244 People
  • 59 Private Offices
  • 5 Conference Rooms
  • 109 Workstations
  • Space is in Excellent Condition
  • Can be combined with additional space(s) for up to 91,320 SF of adjacent space

PROPERTY OVERVIEW

Unlock a ±91,320 SF sublease opportunity at 333 Oyster Point, located within the iconic Portside campus in South San Francisco’s life science core. Surrounded by leading biotech, the space offers flexible configurations for lab, R&D, or office use, supported by robust infrastructure and efficient floor plates. Tenants enjoy direct Bay Trail access, walkable retail, and on-site amenities including a fitness center, conference space, bocce court, and putting green. Built for innovation, ready for growth.

PROPERTY FACTS

Building Type
Office
Year Built
2008
LoopNet Rating
4 Star
Building Height
4 Stories
Building Size
121,760 SF
Building Class
A
Typical Floor Size
30,440 SF
Unfinished Ceiling Height
11’
Parking
108 Surface Parking Spaces

SELECT TENANTS

  • FLOOR
  • TENANT NAME
  • INDUSTRY
  • 2nd
  • Big Sur Bios
  • Professional, Scientific, and Technical Services
  • Multiple
  • NGM Biopharmaceuticals, Inc.
  • Manufacturing
  • Listing ID: 37565196

  • Date on Market: 9/5/2025

  • Last Updated:

  • Address: 333 Oyster Point Blvd, South San Francisco, CA 94080

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