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Highlights

  • Premier Class A medical office space with flexible size options ideal for both growing businesses and established tenants.
  • Positioned at the heart of South Texas Medical Center, with more than 5 million annual patients and almost $18 billion in annual economic impact.
  • Easily accessible location, with proximity to bus lines and Interstates 10 and 410, with abundant on-site parking for staff and clients.
  • Within a state-of-the-art facility that is certified for overnight patient stays, perfect for a wide range of medical specialties.
  • Near top-tier hospital systems like Methodist, St. Luke’s, and University Health, offering endless opportunities for partnership and referral.
  • Supported by a skilled 5-mile workforce of more than 119,000, with more than 58,000 working in education and health services fields.

All Available Spaces(3)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • 2nd Floor, Ste 200
  • 8,217 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Medical
  • Shell Space
  • Now

Suite 200 provides a full-floor opportunity delivered in shell condition.

  • Mostly Open Floor Plan Layout
  • Fits 57 - 183 People
  • 2nd Floor, Ste 210
  • 13,863 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Medical
  • Shell Space
  • Now
  • 3rd Floor, Ste 300
  • 8,190 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Medical
  • Shell Space
  • Now
Space Size Term Rental Rate Space Use Build-Out Available
2nd Floor, Ste 200 8,217 SF Negotiable Upon Request Upon Request Upon Request Upon Request Medical Shell Space Now
2nd Floor, Ste 210 13,863 SF Negotiable Upon Request Upon Request Upon Request Upon Request Medical Shell Space Now
3rd Floor, Ste 300 8,190 SF Negotiable Upon Request Upon Request Upon Request Upon Request Medical Shell Space Now

2nd Floor, Ste 200

Size
8,217 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Medical
Build-Out
Shell Space
Available
Now

2nd Floor, Ste 210

Size
13,863 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Medical
Build-Out
Shell Space
Available
Now

3rd Floor, Ste 300

Size
8,190 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Medical
Build-Out
Shell Space
Available
Now

2nd Floor, Ste 200

Size 8,217 SF
Term Negotiable
Rental Rate Upon Request
Space Use Medical
Build-Out Shell Space
Available Now

Suite 200 provides a full-floor opportunity delivered in shell condition.

  • Mostly Open Floor Plan Layout
  • Fits 57 - 183 People

2nd Floor, Ste 210

Size 13,863 SF
Term Negotiable
Rental Rate Upon Request
Space Use Medical
Build-Out Shell Space
Available Now

3rd Floor, Ste 300

Size 8,190 SF
Term Negotiable
Rental Rate Upon Request
Space Use Medical
Build-Out Shell Space
Available Now

Property Overview

Join a state-of-the-art medical office at the heart of South Texas Medical Center with the premier, turnkey spaces available at Villa Rosa Medical Plaza, located at 5131 Medical Drive in San Antonio. This Class A 68,402-square-foot facility was built in 2010, blending modern infrastructure with a sustainable design. Tenants have the opportunity of leasing 13,863 square feet on the third floor or the full second floor at 22,080 square feet, with flexible demising options that allow businesses of all sizes to find the perfect space for their operations. The spaces are modernized, clean, and secure, offering an energizing and inspiring work environment for employees. Additionally, the suites are certified for overnight patient stays, ideal for a wide variety of medical tenants seeking convenience and cutting-edge amenities. Offering prime placement within South Texas Medical Center, Villa Rosa Medical Plaza positions tenants at the heart of the region’s health care industry, with immediate proximity to San Antonio’s leading hospital systems, including Methodist, St. Luke’s, and University Health. The area sees more than 5 million annual patients and delivers almost $18 billion in annual economic impact, providing endless opportunities for collaboration, partnership, and referral. Ensuring convenient access options for staff and clients, the property enjoys proximity to multiple bus lines and major highways, Interstates 10 and 410, with abundant on-site parking available. The surrounding area is also brimming with quality retailers, restaurants, and service-based amenities, offering convenience for employees. Tenants at Villa Rosa Medical Plaza enjoy exceptionally skilled labor availability within just 3 miles of the property, with a daytime workforce of more than 119,000 supporting over 14,400 businesses. More than 58,000 of these workers are employed in the education and health services fields, ensuring a constant supply of qualified and ambitious new talent to support future growth and expansion. Combining premium, Class A medical office space with a well-connected location at the heart of San Antonio’s health care industry, this rare opportunity offers the perfect choice for businesses seeking to enter or expand in this dynamic market. Contact the Lillibridge team today to schedule a tour and learn about all the advantages of choosing Villa Rosa Medical Plaza.

  • Bus Line
  • Air Conditioning
  • Backup Power / Generators

Property Facts

Building Type
Office
Year Built
2010
Building Height
3 Stories
Building Size
68,402 SF
Building Class
B
Typical Floor Size
22,801 SF
Unfinished Ceiling Height
12’
Parking
100 Surface Parking Spaces
20 Covered Parking Spaces
Moderately walkable
70/100
Exceptionally drivable
90/100
Some public transit
50/100
Fairly bikeable
50/100
  • Listing ID: 30979117

  • Date on Market: 5/28/2025

  • Last Updated:

  • Address: 5131 Medical Dr, San Antonio, TX 78229

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