Share This Listing

Message

967 characters remaining

Hmm, there seems to have been an error sending your message. Please try again.

Your email has been sent.

Still interested?

Contact the broker for more information about this property

All Available Space(1)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • 1st Floor
  • 3,083 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Retail
  • Full Build-Out
  • Now

The Innovation Quarter is a dynamic, mixed-use innovation district in the heart of downtown Winston-Salem. It's designed to bring research, business, education, and community into close proximity. Where ideas connect and collaboration follows. Anchored by Wake Forest University School of Medicine, the district is home to more than 4,500 workers, 115 companies, and nearly 2,000 students. From biomedical sciences and clinical services to technology, data, and advanced materials, the Innovation Quarter supports a diverse and growing community of thinkers, builders, and problem-solvers. This space is also close to residents of Plant 64 and Link IQ apartments. See floorplan for retail space.

  • Fully Built-Out as Standard Retail Space
Space Size Term Rental Rate Space Use Build-Out Available
1st Floor 3,083 SF Negotiable Upon Request Upon Request Upon Request Upon Request Retail Full Build-Out Now

1st Floor

Size
3,083 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Retail
Build-Out
Full Build-Out
Available
Now

1st Floor

Size 3,083 SF
Term Negotiable
Rental Rate Upon Request
Space Use Retail
Build-Out Full Build-Out
Available Now

The Innovation Quarter is a dynamic, mixed-use innovation district in the heart of downtown Winston-Salem. It's designed to bring research, business, education, and community into close proximity. Where ideas connect and collaboration follows. Anchored by Wake Forest University School of Medicine, the district is home to more than 4,500 workers, 115 companies, and nearly 2,000 students. From biomedical sciences and clinical services to technology, data, and advanced materials, the Innovation Quarter supports a diverse and growing community of thinkers, builders, and problem-solvers. This space is also close to residents of Plant 64 and Link IQ apartments. See floorplan for retail space.

  • Fully Built-Out as Standard Retail Space

Site Plan

Property Facts

Building Type
Office
Year Built
1926
Building Height
5 Stories
Building Size
96,000 SF
Building Class
C
Typical Floor Size
22,000 SF
Moderately walkable
70/100
Moderately drivable
60/100
Limited public transit
30/100
Fairly bikeable
50/100

Nearby Major Retailers

F45 Training, Inc.
Wildfire LLC
Famous Toastery
Top Tier Crossfit
Truist
First Horizon Bank
Compare Foods
Pinnacle Bank
Food Lion
Wells Fargo
  • Listing ID: 41314330

  • Date on Market: 7/16/2026

  • Last Updated:

  • Address: 577 Vine St, Winston-Salem, NC 27101

Contact the Leasing Agent

577 Vine St

Have an account? Log In

What's your inquiry about?*

Select Option

Select at least one option

Preferred Date*

Preferred date is required

How much space do you need? (optional)

Select Size

First Name*

Last Name*

Email*

Email address is required

Phone*

Ext (optional)

Company (optional)

Message*

Message is required

{{getContactFormMessageFieldCharacterCount()}} out of 600

New to LoopNet? No problem. We'll automatically create a free account for you. By clicking the button, you agree to LoopNet's Terms of Use and Privacy Notice.

Hmm, there seems to have been an error sending your message. Please refresh the page and try again.

Your message has been sent.
Link copied
Your LoopNet account has been created!

Please Share Your Feedback

We welcome any feedback on how we can improve LoopNet to better serve your needs.
X
{{ getErrorText(feedbackForm.starRating, "rating") }}
255 character limit ({{ remainingChars() }} charactercharacters remainingover)
{{ getErrorText(feedbackForm.msg, "rating") }}
{{ getErrorText(feedbackForm.fname, "first name") }}
{{ getErrorText(feedbackForm.lname, "last name") }}
{{ getErrorText(feedbackForm.phone, "phone number") }}
{{ getErrorText(feedbackForm.phonex, "phone extension") }}
{{ getErrorText(feedbackForm.email, "email address") }}