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344-346 E 110th St 3,000 SF of 4-Star Office/Medical Space Available in New York, NY 10029
Highlights
- Steps from the 110th Street 6 train and major bus routes for strong commuter access.
- High-visibility frontage along an active East Harlem commercial corridor.
- Surrounded by dense residential population and consistent neighborhood foot traffic.
All Available Space(1)
Display Rental Rate as
- Space
- Size
- Term
- Rental Rate
- Space Use
- Build-Out
- Available
Base Rent: Upon Request Term: Flexible Possession: Immediate Notes: Lower-Level Medical/Office Space with Entrance Through Ground Floor | All Uses Considered Description: Located in the heart of East Harlem, 344–346 East 110th Street offers a versatile lower-level space suitable for medical, office, or professional use in the base of a brand new residential building. Just steps from the 110th Street 6 train station and major bus routes, the property provides excellent accessibility for staff and clients. Surrounded by residential developments, schools, and community institutions, this location benefits from strong neighborhood demographics and growing demand. Features: * Efficient layout adaptable for medical suites, private offices, or community use * Conveniently located near the 6 train and multiple bus lines * Strong neighborhood density with schools, retail, and housing nearby * Flexible lease terms available
- Listed lease rate plus proportional share of the utilities and cleaning cost
- Open Floor Plan Layout
- Open-Plan
- Fully Built-Out as Professional Services Office
- Space is in Excellent Condition
- Flexible lease terms available
| Space | Size | Term | Rental Rate | Space Use | Build-Out | Available |
| Lower Level | 3,000 SF | 1-10 Years | $32.00 /SF/YR $2.67 /SF/MO $96,000 /YR $8,000 /MO | Office/Medical | Full Build-Out | Now |
Lower Level
| Size |
| 3,000 SF |
| Term |
| 1-10 Years |
| Rental Rate |
| $32.00 /SF/YR $2.67 /SF/MO $96,000 /YR $8,000 /MO |
| Space Use |
| Office/Medical |
| Build-Out |
| Full Build-Out |
| Available |
| Now |
Lower Level
| Size | 3,000 SF |
| Term | 1-10 Years |
| Rental Rate | $32.00 /SF/YR |
| Space Use | Office/Medical |
| Build-Out | Full Build-Out |
| Available | Now |
Base Rent: Upon Request Term: Flexible Possession: Immediate Notes: Lower-Level Medical/Office Space with Entrance Through Ground Floor | All Uses Considered Description: Located in the heart of East Harlem, 344–346 East 110th Street offers a versatile lower-level space suitable for medical, office, or professional use in the base of a brand new residential building. Just steps from the 110th Street 6 train station and major bus routes, the property provides excellent accessibility for staff and clients. Surrounded by residential developments, schools, and community institutions, this location benefits from strong neighborhood demographics and growing demand. Features: * Efficient layout adaptable for medical suites, private offices, or community use * Conveniently located near the 6 train and multiple bus lines * Strong neighborhood density with schools, retail, and housing nearby * Flexible lease terms available
- Listed lease rate plus proportional share of the utilities and cleaning cost
- Fully Built-Out as Professional Services Office
- Open Floor Plan Layout
- Space is in Excellent Condition
- Open-Plan
- Flexible lease terms available
About the Property
Located at 344 East 110th Street in East Harlem, this approximately 3,000 SF lower-level medical/commercial space offers a rare opportunity for medical users, adult daycare operators, and community facility businesses seeking a functional, accessible, and strategically located space in one of Manhattan’s fastest-evolving neighborhoods. The space is ADA compliant, features two bathrooms, central AC and heating, elevator access, and can be delivered turnkey or built to suit a tenant’s operational needs. The property also includes a modified elevator/lift system, making accessibility for patients, clients, staff, and visitors seamless. Positioned on the eastern side of East Harlem near 1st Avenue, the property benefits from a strong surrounding residential population, creating a built-in client base for medical, wellness, or community-oriented uses. The building itself is professionally maintained with on-site support and residences above, helping create consistent daily activity within the property. The block is quiet while still being conveniently located near neighborhood amenities including delis, retail businesses, and nearby self-storage facilities. Transportation and regional connectivity are major highlights of this location. The property offers quick access to the Willis Avenue Bridge, Madison Avenue Bridge, FDR Drive, and I-87, allowing efficient travel throughout Manhattan, the Bronx, Westchester, and beyond. Employees and visitors can easily access the space via nearby subway lines at 110th Street, while Metro-North service at 125th Street is only a short commute away. The location also benefits from proximity to the RFK Bridge, providing convenient access to Queens and other boroughs. East Harlem has continued to experience significant residential and commercial development in recent years, with the future Second Avenue Subway expansion expected to further improve accessibility and long-term neighborhood growth. Constructed in 2016, the property presents a first-time occupancy opportunity within a modern residential building. The combination of accessibility, infrastructure, residential density, and strong transportation access makes this an ideal opportunity for healthcare providers, adult daycare operators, therapy practices, nonprofit/community facility users, or other professional operators seeking a well-located Manhattan space.
Property Facts
| Total Space Available | 3,000 SF | Apartment Style | Mid-Rise |
| No. Units | 33 | Building Size | 33,568 SF |
| Property Type | Multifamily | Year Built | 2014 |
| Property Subtype | Apartment |
| Total Space Available | 3,000 SF |
| No. Units | 33 |
| Property Type | Multifamily |
| Property Subtype | Apartment |
| Apartment Style | Mid-Rise |
| Building Size | 33,568 SF |
| Year Built | 2014 |
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344-346 E 110th St
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