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425 Eccles Ave 11,398 - 22,796 SF of Flex Space Available in South San Francisco, CA 94080

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Highlights

  • Move-in ready lab environment with existing casework, chemical fume hoods, and dedicated backup power.
  • Walkable access to Caltrain with rapid reach to Highway 101, 380, and 280, plus convenient ferry and airport connections.
  • Freestanding control and identity near Oyster Point’s leading life science campuses and employers.
  • Functional layout with multiple collaboration areas, amenity lounge, and efficient shipping, receiving, and storage.

Features

Standard Parking Spaces
49

All Available Spaces(2)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Condition
  • Available
  • 1st Floor
  • 11,398 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Flex
  • Full Build-Out
  • Now

Position your team in a plug-and-play, stand-alone lab and office building in the heart of South San Francisco’s Oyster Point life science cluster. The building offers a continuous glass line and large open lab areas supported by dedicated backup power and floor drains. Existing casework and 6-foot chemical fume hoods are in place within each lab, with partial lab equipment available for tenant use to accelerate move-in. Multiple conference rooms and a large amenity lounge support collaboration, while on-site shipping and receiving, private storage, and haz-mat rooms streamline operations. Office and lab furniture can be provided for a turnkey setup.

  • Reception Area
  • Plug & Play
  • Open office bullpen, lobby/reception
  • Additional hoods can be made available
  • Laboratory
  • Ground floor arranged with multiple labs
  • IT closet and storage
  • 2nd Floor
  • 11,398 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Flex
  • Full Build-Out
  • Now

Position your team in a plug-and-play, stand-alone lab and office building in the heart of South San Francisco’s Oyster Point life science cluster. The building offers a continuous glass line and large open lab areas supported by dedicated backup power and floor drains. Existing casework and 6-foot chemical fume hoods are in place within each lab, with partial lab equipment available for tenant use to accelerate move-in. Multiple conference rooms and a large amenity lounge support collaboration, while on-site shipping and receiving, private storage, and haz-mat rooms streamline operations. Office and lab furniture can be provided for a turnkey setup.

  • Laboratory
  • Second floor includes open office areas
  • Kitchen with amenity lounge
  • Plug & Play
  • Several private offices, labs, conference rooms
  • Plug-and-play lab and office
Space Size Term Rental Rate Space Use Condition Available
1st Floor 11,398 SF Negotiable Upon Request Upon Request Upon Request Upon Request Flex Full Build-Out Now
2nd Floor 11,398 SF Negotiable Upon Request Upon Request Upon Request Upon Request Flex Full Build-Out Now

1st Floor

Size
11,398 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Flex
Condition
Full Build-Out
Available
Now

2nd Floor

Size
11,398 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Flex
Condition
Full Build-Out
Available
Now

1st Floor

Size 11,398 SF
Term Negotiable
Rental Rate Upon Request
Space Use Flex
Condition Full Build-Out
Available Now

Position your team in a plug-and-play, stand-alone lab and office building in the heart of South San Francisco’s Oyster Point life science cluster. The building offers a continuous glass line and large open lab areas supported by dedicated backup power and floor drains. Existing casework and 6-foot chemical fume hoods are in place within each lab, with partial lab equipment available for tenant use to accelerate move-in. Multiple conference rooms and a large amenity lounge support collaboration, while on-site shipping and receiving, private storage, and haz-mat rooms streamline operations. Office and lab furniture can be provided for a turnkey setup.

  • Reception Area
  • Laboratory
  • Plug & Play
  • Ground floor arranged with multiple labs
  • Open office bullpen, lobby/reception
  • IT closet and storage
  • Additional hoods can be made available

2nd Floor

Size 11,398 SF
Term Negotiable
Rental Rate Upon Request
Space Use Flex
Condition Full Build-Out
Available Now

Position your team in a plug-and-play, stand-alone lab and office building in the heart of South San Francisco’s Oyster Point life science cluster. The building offers a continuous glass line and large open lab areas supported by dedicated backup power and floor drains. Existing casework and 6-foot chemical fume hoods are in place within each lab, with partial lab equipment available for tenant use to accelerate move-in. Multiple conference rooms and a large amenity lounge support collaboration, while on-site shipping and receiving, private storage, and haz-mat rooms streamline operations. Office and lab furniture can be provided for a turnkey setup.

  • Laboratory
  • Plug & Play
  • Second floor includes open office areas
  • Several private offices, labs, conference rooms
  • Kitchen with amenity lounge
  • Plug-and-play lab and office

Property Overview

The location delivers immediate connectivity to Highway 101, with quick links to Highway 380 and 280. Caltrain’s South San Francisco station is walkable, the South San Francisco Ferry Terminal is nearby, and San Francisco International Airport is roughly a 10-minute drive. Downtown San Francisco is approximately 20 minutes away. The site is surrounded by nationally recognized life science campuses, including Gateway of Pacific, Kilroy Oyster Point, and Genentech, giving tenants proximity to talent, suppliers, and collaborators. As a freestanding building with on-site parking and a backup generator with ample power, 425 Eccles Avenue suits single-tenant occupancy or can be configured for multiple users seeking efficient lab and office space in a premier Bay Area innovation market.

Property Facts

Building Size
22,796 SF
Lot Size
0.97 AC
Year Built/Renovated
1975/2018
Zoning
Biotech

Select Tenants

  • Floor
  • Tenant Name
  • Industry
  • Multiple
  • Convergent Genomics
  • Professional, Scientific, and Technical Services
  • Listing ID: 39290788

  • Date on Market: 2/2/2026

  • Last Updated:

  • Address: 425 Eccles Ave, South San Francisco, CA 94080

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