580 Dubuque Ave
South San Francisco, CA 94080
Flex Property For Lease · 330,300 SF

580 Dubuque Avenue is a purpose-built office and life science campus opportunity positioned directly adjacent to the South San Francisco Caltrain Station, providing exceptional regional connectivity throughout the Bay Area. The eight-story development is designed with approximately 330,300 RSF and offers flexible floor plates that support a mix of laboratory and office environments. Occupants benefit from immediate access to Highway 101, convenient connections to San Francisco International Airport, and proximity to South San Francisco's established biotechnology cluster. The project features a modern amenity program that includes a fitness center, café, lounge areas, conference and training facilities, bike storage, lockers, showers, and outdoor gathering spaces. Sustainability-focused design elements include all-electric mechanical systems, solar shading, recycled water irrigation, electric vehicle charging infrastructure, and drought-tolerant landscaping. Combined with prominent visibility along Dubuque Avenue and direct access to transit, the property offers an efficient workplace environment for innovative companies seeking a highly connected South San Francisco location.