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East Grand Avenue South San Francisco, CA 94080 22,250 - 59,782 SF of Flex Space Available

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Park Highlights

  • Versatile spec suites within South San Francisco’s premier life science campus, with space options for 22,250 and 37,532 square feet.
  • Located minutes from the Highway 101 interchange, walkable from the SSF Caltrain Station and under 10 minutes from San Francisco Intl Airport.
  • Exceptional amenity package, including an on-site restaurant, an activated wellness center, a conferencing center, and ample parking with EV chargers.
  • Tenants are placed within minutes of desirable urban amenities, including popular restaurants, retail, hotels, and service-based businesses.

Park Facts

Total Space Available 59,782 SF
Park Type Office Park

All Available Spaces(2)

Display Rental Rate as

East Grand Avenue
269 E Grand Ave - Building 2
22,250 - 59,782 SF | Upon Request Upon Request Upon Request Upon Request Upon Request Upon Request | View Building Details
Building Type/Class
Office/A
Year Built
2014
Building Size
111,038 SF
Building Height
3 Stories
Typical Floor Size
34,205 SF
  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Condition
  • Available
  • 2nd Floor
  • 22,250 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Flex
  • Spec Suite
  • September 01, 2026

Lab build out

  • The office offers large, open floorplates for flex
  • The building includes an Activated Wellness Center
  • Guests gather in the Amenity Hub Atrium for work.
  • 3rd Floor
  • 37,532 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Flex
  • Spec Suite
  • September 01, 2026

Office build out

  • The office offers large, open floorplates for flex
  • The building includes an Activated Wellness Center
  • Guests gather in the Amenity Hub Atrium for work.
Space Size Term Rental Rate Space Use Condition Available
2nd Floor 22,250 SF Negotiable Upon Request Upon Request Upon Request Upon Request Flex Spec Suite September 01, 2026
3rd Floor 37,532 SF Negotiable Upon Request Upon Request Upon Request Upon Request Flex Spec Suite September 01, 2026
East Grand Avenue
269 E Grand Ave - Building 2
22,250 - 59,782 SF | Upon Request Upon Request Upon Request Upon Request Upon Request Upon Request | View Building Details
Building Type/Class
Office/A
Year Built
2014
Building Size
111,038 SF
Building Height
3 Stories
Typical Floor Size
34,205 SF

269 E Grand Ave - 2nd Floor

Size
22,250 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Flex
Condition
Spec Suite
Available
September 01, 2026

269 E Grand Ave - 3rd Floor

Size
37,532 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Flex
Condition
Spec Suite
Available
September 01, 2026

269 E Grand Ave - 2nd Floor

Size 22,250 SF
Term Negotiable
Rental Rate Upon Request
Space Use Flex
Condition Spec Suite
Available September 01, 2026

Lab build out

  • The office offers large, open floorplates for flex
  • Guests gather in the Amenity Hub Atrium for work.
  • The building includes an Activated Wellness Center

269 E Grand Ave - 3rd Floor

Size 37,532 SF
Term Negotiable
Rental Rate Upon Request
Space Use Flex
Condition Spec Suite
Available September 01, 2026

Office build out

  • The office offers large, open floorplates for flex
  • Guests gather in the Amenity Hub Atrium for work.
  • The building includes an Activated Wellness Center

Select Tenants at This Property

  • Floor
  • Tenant Name
  • Industry
  • 1st
  • Bright Horizons
  • Health Care and Social Assistance
  • Multiple
  • Insitro, Inc.
  • Manufacturing
  • Multiple
  • Merck
  • Manufacturing
  • 3rd
  • Molecular Stethoscope
  • Information
  • Multiple
  • Verily
  • Professional, Scientific, and Technical Services

Park Overview

Join a premier life science campus with the versatile spec suites available for lease at East Grand Avenue in South San Francisco, California. Coming available in September of 2026, these modern spaces include options for 22,250 and 37,532 square feet, offering an ideal canvas for growing teams and institutional businesses. This incredible business destination offers a range of exceptional on-site amenities that form an idyllic and energizing hub for corporate activity. Tenants enjoy access to an activated wellness center, a restaurant, sports courts, and a 300-person conferencing center. There is also abundant on-site parking available with EV charging stations, as well as generous outdoor space with outdoor walking trails and lush landscaping. Situated in a prominent location close to the Highway 101 interchange, this rare offer places businesses in an easily accessible commercial hub. The campus is just a short walk to the SSF Caltrain station, and less than 10 minutes from SFO airport. The surrounding area presents a wide array of desirable urban amenities, including top-rated shopping, dining, recreation, and hotels.

  • Listing ID: 37277544

  • Date on Market: 8/14/2025

  • Last Updated:

  • Address: 249 E Grand Ave, South San Francisco, CA 94080

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